Evidence map›Paper›PMID 30935100›Full record

ArticleMolecules (Basel, Switzerland)2019

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from

Yu Zhang, Masuo Goto, Akifumi Oda, Pei-Ling Hsu, Ling-Li Guo, Yan-Hui Fu, Susan L Morris-Natschke, Ernest Hamel, Kuo-Hsiung Lee, Xiao-Jiang Hao

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Retrospection ofMini reviews in medicinal chemistry · 2026
    Review
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  3. An In-depth Review onAnti-cancer agents in medicinal chemistry · 2025
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  4. Lead/Drug Discovery from Natural Resources.Molecules (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Yu ZhangKey Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. zhangyu@mail.kib.ac.cn.ORCID 0000-0001-8562-344X
Masuo GotoNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. goto@med.unc.edu.ORCID 0000-0002-9659-1460
Akifumi OdaGraduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, Aichi 468-8503, Japan. oda@meijo-u.ac.jp.
Pei-Ling HsuNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. peiling96@livemail.tw.
Ling-Li GuoKey Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. guolingli@mail.kib.ac.cn.
Yan-Hui FuKey Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. fuyanhui80@163.com.
Susan L Morris-NatschkeNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. susan_natschke@unc.edu.
Ernest HamelScreening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. hamele@dc37a.nci.nih.gov.
Kuo-Hsiung LeeNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. khlee@unc.edu.ORCID 0000-0002-6562-0070
Xiao-Jiang HaoKey Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. haoxj@mail.kib.ac.cn.
University of North Carolina at Chapel Hill · USKunming Institute of Botany · CNFrederick National Laboratory for Cancer Research · USMeijo University · JP

Funding

Novel Antitumor AgentsR01CA177584 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, KUO-HSIUNG · 2013 to 2017
$1.9M
Applied Basic Research Key Project of Yunnan 2018FA049CAS "Light of West China" Program to Y. ZhangEshelman Institute for Innovation, Chapel Hill, North Carolina to M. GotoFoundation for the National Institutes of Health CA177584National Natural Science Foundation of China 81874295NCI NIH HHS R01 CA177584Young Academic and Technical Leader Raising Foundation of Yunnan Province to Y. ZhangYouth Innovation Promotion Association of CAS 2015323
6 · The paper itself

Abstract

Monoterpenoid indole alkaloids are structurally diverse natural products found in plants of the family Apocynaceae. Among them, vincristine and its derivatives are well known for their anticancer activity.

Indexed as

Antineoplastic AgentsAspidospermaCell CycleCell Line, TumorCell ProliferationHumansModels, MolecularMolecular ConformationMolecular StructureProtein BindingProtein MultimerizationSecologanin Tryptamine AlkaloidsStructure-Activity RelationshipTubulinTubulin ModulatorsAntineoplastic AgentsSecologanin Tryptamine AlkaloidsTubulinTubulin Modulatorsantiproliferative activityaspidosperma-typeBousigonia mekongensismonoterpenoid indole alkaloidstubulin inhibitor

Identifiers

PMID30935100
PMCPMC6480704
OpenAlexW2932504359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.