ArticleInternational journal of molecular sciences2019
N-Linked Glycosylation and Near-Infrared Spectroscopy in the Diagnosis of Prostate Cancer.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Glycomics in Human Diseases and Its Emerging Role in Biomarker Discovery.Biomedicines · 2025Review
- The Association between UrineBiomedicines · 2024Article
- Prognostic Features of Near-Infrared Spectroscopy Following Primary Radical Prostatectomy.Cancers · 2021Article
- A Tissue Section-Based Near-Infrared Spectroscopical Analysis of Salivary Gland Tumors.Cancers · 2021Article
- Identification of crucial genes and pathways associated with prostate cancer in multiple databases.The Journal of international medical research · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPerforming a prostate biopsy is the most robust and reliable way to diagnose prostate cancer (PCa), and to determine the disease grading. As little to no biochemical markers for prostate tissue exist, we explored the possibilities of tissue N-glycosylation and near-infrared spectroscopy (NIR) in PCa diagnosis.
methodsTissue specimens from 100 patients (benign prostate hyperplasia (BPH),
resultsA difference was observed for the tissue of N-glycosylation between the benign and malignant tissue. These differences were located in the fycosylation ratios and the total amount of bi- and tetra-antennary structures (all
conclusionsWe have demonstrated biochemical changes in the N-glycan profile of prostate tissue, which allows for the distinction between malignant and benign tissue, as well as between various Gleason scores. These changes can be correlated to the changes observed in the NIR spectra. This could possibly further improve the histological assessment of PCa diagnosis, although further method validation is needed.
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