An Efficient, One-Pot Transamidation of 8-Aminoquinoline Amides Activated by Tertiary-Butyloxycarbonyl.

Wengang Wu, Jun Yi, Huipeng Xu, Shuangjun Li, Rongxin Yuan

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.7field-weighted citation impact, top 37% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

Synthesis of β,β-Dinaphthyl Amino Acids: Towards Molecular Gearing in Peptides and Mini-Proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
Article
Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process.Molecules (Basel, Switzerland) · 2020
Article
Synthesis of Elaborate Benzofuran-2-carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C-H Arylation and Transamidation Chemistry.Molecules (Basel, Switzerland) · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wengang WuCollege of Chemistry, Chemical Engineering and Materials Science of Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China. 20155209006@suda.edu.cn.

Jun YiJiangsu Laboratory of Advanced Functional Material, School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, China. yijun08@mail.ustc.edu.cn.ORCID 0000-0002-4984-6125

Huipeng XuJiangsu Laboratory of Advanced Functional Material, School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, China. xuhp150315217cslg@126.com.

Shuangjun LiJiangsu Laboratory of Advanced Functional Material, School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, China. lisj150315206cslg@126.com.

Rongxin YuanJiangsu Laboratory of Advanced Functional Material, School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, China. yuanrx@cslg.edu.cn.

Suzhou University of Technology · CNSoochow University · CN

Funding

National Natural Science Foundation of China 21602017Natural Science Foundation of Jiangsu Province BK20160405Research Start-up Fund of Changshu Institute of Technology XZ1508University Science Research Project of Jiangsu Province 16KJB150001

6 · The paper itself

Abstract

The efficient, one-pot access to the transamidation of 8-aminoquinoline (8-AQ), notorious for its harsh removal conditions, has been widely employed as an auxiliary in C⁻H functionalization reactions due to its strong directing ability. In this study, the facile and mild Boc protection of the corresponding 8-AQ amide was critical to activate the amide C

Indexed as

AmidesAminesAminoquinolinesCatalysisMolecular StructureTemperature8-aminoquinolineAmidesAminesAminoquinolinesamide C(acyl)–N cleavagedirecting group removalN-heterocyclic carbeneone-pot reactionpalladium

Identifiers

PMID30934862

DOI10.3390/molecules24071234

PMCPMC6480081

OpenAlexW2928293396

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.