Evidence map›Paper›PMID 30934690›Full record

ArticleInternational journal of molecular sciences2019

Cell Type-Specific p38δ Targeting Reveals a Context-, Stage-, and Sex-Dependent Regulation of Skin Carcinogenesis.

Alexi Kiss, Aaron C Koppel, Emily Murphy, Maxwell Sall, Meral Barlas, Grace Kissling, Tatiana Efimova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. p38δ genetic ablation protects female mice from anthracycline cardiotoxicity.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexi KissDepartment of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA. kiss@gwu.edu.
Aaron C KoppelDepartment of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA. akoppel@gwu.edu.ORCID 0000-0003-4887-2695
Emily MurphyDepartment of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA. emurphy@mfa.gwu.edu.
Maxwell SallDepartment of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA. maxsall@gwmail.gwu.edu.
Meral BarlasDepartment of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA. meralbarlas@gwmail.gwu.edu.
Grace KisslingBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. GKissling@msn.com.
Tatiana EfimovaDepartment of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA. tefimova@gwu.edu.
George Washington University · USGeorgetown University · USNational Institute of Environmental Health Sciences · US

Funding

National Institutes of Health R01 CA133038
6 · The paper itself

Abstract

Activation and/or upregulated expression of p38δ are demonstrated in human skin malignancies including cutaneous squamous cell carcinoma, suggesting a role for p38δ in skin carcinogenesis. We previously reported that mice with germline deletion of the p38δ gene are significantly protected from chemical skin carcinogenesis. Here, we investigated the effects of cell-selective targeted ablation of p38δ in keratinocytes and in immune (myeloid) cells on skin tumor development in a two-stage 7,12-dimethylbenz(

Indexed as

Sex Characteristics9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogenesisCarcinoma, Squamous CellCell ProliferationCytokinesDisease ProgressionFemaleGene DeletionInflammation MediatorsKeratinocytesMaleMice, KnockoutMitogen-Activated Protein Kinase 13Myeloid Cells9,10-Dimethyl-1,2-benzanthraceneCytokinesInflammation MediatorsMitogen-Activated Protein Kinase 13Tetradecanoylphorbol Acetateconditional knockout micekeratinocytesmyeloid cellsp38δ/MAPK13skin carcinogenesis

Identifiers

PMID30934690
PMCPMC6479675
OpenAlexW2923804334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.