SynthesisNutrients2019
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis.
Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 16 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 16 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- C-Terminal Agrin Fragment as a Biomarker for Sarcopenia: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Dysregulation of melatonin rhythm in Parkinson's and Huntington's disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports.BMC pulmonary medicine · 2024Pooled it
- Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: A meta-analysis of randomized controlled trials with trial sequential analysis.Frontiers in nutrition · 2023Pooled it
- Vitamins C and D and COVID-19 Susceptibility, Severity and Progression: An Evidence Based Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Agronomic biofortification of food crops: An emerging opportunity for global food and nutritional security.Frontiers in plant science · 2022Pooled it
- Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Micronutrients Deficiency, Supplementation and Novel Coronavirus Infections-A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Mortality in septic patients treated with vitamin C: a systematic meta-analysis.Critical care (London, England) · 2021Pooled it
- The Challenges and Effects of Ascorbic Acid Treatment of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.Frontiers in nutrition · 2021Pooled it
- Could Vitamins Help in the Fight Against COVID-19?Nutrients · 2020Pooled it
- Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association.Nutrients · 2020Pooled it
- Pooled it
- Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials.Diabetes & metabolic syndromePooled it
- Effect of vitamin C in critically ill patients with sepsis and septic shock: A meta-analysis.Science progressPooled it
- Abrupt termination of vitamin C from ICU patients may increase mortality: secondary analysis of the LOVIT trial.European journal of clinical nutrition · 2023Trial
- Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial.Critical care (London, England) · 2022Trial
- Trial
- Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study.Scientific reports · 2021Trial
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.