Evidence map›Paper›PMID 30934578›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents.

Niu-Niu Zhang, Bai-Jiao An, Yan Zhou, Xing-Shu Li, Ming Yan

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Niu-Niu ZhangInstitute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangniuniuu@yeah.net.ORCID 0000-0002-1763-4398
Bai-Jiao AnInstitute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. 15521085401@163.com.
Yan ZhouInstitute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhouy598@mail2.sysu.edu.cn.
Xing-Shu LiInstitute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lixsh@mail.sysu.edu.cn.
Ming YanInstitute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. yanming@mail.sysu.edu.cn.ORCID 0000-0001-9888-0744

Funding

National Natural Science Foundation of China 21772240the Guangzhou Science Technology and Innovation Commission 201707010210
6 · The paper itself

Abstract

Inspired by the potent inhibition activity of the c-Met (mesenchymal-epithelial transition factor) inhibitor Tepotinib, a series of new Tepotinib derivatives were synthesized and evaluated for their ability to act as antiproliferative agents to find the leading compounds with good activity and limited side effects. Among them, compound

Indexed as

Antineoplastic AgentsCell Line, TumorCell MovementCell ProliferationChemistry Techniques, SyntheticHumansPhosphorylationProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-metSignal TransductionStructure-Activity RelationshipAntineoplastic AgentsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-met97H cellsantiproliferative agentsc-Met inhibitorlow toxicity

Identifiers

PMID30934578
PMCPMC6470795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.