ArticlePsychiatry investigation2019
White Matter Tract-Cognitive Relationships in Children with High-Functioning Autism Spectrum Disorder.
Article in Psychiatry investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Thalamo-cortical white matter connectivity-defined thalamic subarea volumes predict individual delay discounting.Molecular psychiatry · 2026Article
- Altered white matter connectivity is linked to language abilities in children with autism spectrum disorder: An automated fiber quantification study.Frontiers in psychiatry · 2025Article
- Alterations of White Matter Microstructure in Primary Aldosteronism Patients With Normal Cognitive Functioning Using Diffusion Tensor Imaging.International journal of general medicine · 2025Article
- Alterations in the white matter fiber tracts of preschool-aged children with autism spectrum disorder: an automated fiber quantification study.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Brain white matter microstructure abnormalities in children with optimal outcome from autism: a four-year follow-up study.Scientific reports · 2022Article
- Associations Between White Matter Microstructures and Cognitive Functioning in 8-Year-Old Children: A Track-Weighted Imaging Study.Journal of child neurology · 2022Article
- Association of Reduced Tract Integrity with Social Communication Deficits in Preschool Autism Children: A Tract-Based Spatial Statistics Study.Neuropsychiatric disease and treatment · 2021Article
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Authors and funding
9 authors.
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Abstract
objectiveThe purpose of the present study was to clarify the relationship between white matter tracts and cognitive symptoms in children with high-functioning autism spectrum disorder (ASD).
methodsWe examined the cognitive functions of 17 children with high-functioning ASD and 18 typically developing (TD) controls and performed diffusion tensor imaging (DTI) tractography. We compared the results between the groups and investigated the correlations between the cognitive scores and DTI parameters within each group.
resultsThe Comprehension scores in the ASD group exhibited a positive correlation with mean diffusivity (MD) in the forceps minor (F minor). In the TD group, the Comprehension scores were positively correlated with fractional anisotropy (FA) in the right inferior fronto-occipital fasciculus (IFO) and left anterior thalamic radiation (ATR), and negatively correlated with MD in the left ATR, radial diffusivity (RD) in the right IFO, and RD in the left ATR. Additionally, a positive correlation was observed between the Matching Numbers scores and MD in the left uncinate fasciculus and F minor, and RD in the F minor. Furthermore, the Sentence Questions scores exhibited a positive correlation with RD in the right inferior longitudinal fasciculus. Relative to TD controls, the specific tract showing a strong correlation with the cognitive scores was reduced in the ASD group.
conclusionOur findings indicate that white matter tracts connecting specific brain areas may exhibit a weaker relationship with cognitive functions in children with ASD, resulting in less efficient cognitive pathways than those observed in TD children.
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