ArticlePLoS pathogens2019
Non-canonical fungal G-protein coupled receptors promote Fusarium head blight on wheat.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- The role of fungal G protein-coupled receptors in interspecies cell-cell communication.FEMS microbiology reviews · 2026Review
- Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis.PLoS pathogens · 2025Article
- The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis.PLoS pathogens · 2025Article
- Fungal Stress Responses and the Importance of GPCRs.Journal of fungi (Basel, Switzerland) · 2025Review
- A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis.PLoS pathogens · 2025Article
- The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors.Nature microbiology · 2024Article
- Identification and functional characterisation of a locus for target site integration in Fusarium graminearum.Fungal biology and biotechnology · 2024Article
- Antifungal Effect of Metabolites from Bacterial Symbionts of Entomopathogenic Nematodes on Fusarium Head Blight of Wheat.Journal of fungi (Basel, Switzerland) · 2024Article
- Genetic and Transcriptional Regulatory Mechanisms of Lipase Activity in the Plant Pathogenic Fungus Fusarium graminearum.Microbiology spectrum · 2023Article
- Overview of fungal terpene synthases and their regulation.World journal of microbiology & biotechnology · 2023Review
- Review
- Deletion of all three MAP kinase genes results in severe defects in stress responses and pathogenesis in Fusarium graminearum.Stress biology · 2022Article
- The vesicular trafficking system component MIN7 is required for minimizing Fusarium graminearum infection.Journal of experimental botany · 2021Article
- Comparative genomics reveals a core gene toolbox for lifestyle transitions in Hypocreales fungi.Environmental microbiology · 2021Article
- Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects.Science China. Life sciences · 2021Article
- Prey sensing and response in a nematode-trapping fungus is governed by the MAPK pheromone response pathway.Genetics · 2021Article
- Heterotrimeric G-Protein Signaling Is Required for Cellulose Degradation in Neurospora crassa.mBio · 2020Article
- Epigenetic regulation of gene expression improves Fusarium head blight resistance in durum wheat.Scientific reports · 2020Article
- Article
- Functional evaluation of a homologue of plant rapid alkalinisation factor (RALF) peptides in Fusarium graminearum.Fungal biology · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Fusarium Head Blight (FHB) is the number one floral disease of cereals and poses a serious health hazard by contaminating grain with the harmful mycotoxin deoxynivalenol (DON). Fungi adapt to fluctuations in their environment, coordinating development and metabolism accordingly. G-protein coupled receptors (GPCRs) communicate changes in the environment to intracellular G-proteins that direct the appropriate biological response, suggesting that fungal GPCR signalling may be key to virulence. Here we describe the expansion of non-classical GPCRs in the FHB causing pathogen, Fusarium graminearum, and show that class X receptors are highly expressed during wheat infection. We identify class X receptors that are required for FHB disease on wheat, and show that the absence of a GPCR can cause an enhanced host response that restricts the progression of infection. Specific receptor sub-domains are required for virulence. These non-classical receptors physically interact with intracellular G-proteins and are therefore bona fide GPCRs. Disrupting a class X receptor is shown to dysregulate the transcriptional coordination of virulence traits during infection. This amounts to enhanced wheat defensive responses, including chitinase and plant cell wall biosynthesis, resulting in apoplastic and vascular occlusions that impede infection. Our results show that GPCR signalling is important to FHB disease establishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.