SynthesisPloS one2019
The role of primary intraocular lens implantation in the risk of secondary glaucoma following congenital cataract surgery: A systematic review and meta-analysis.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Glaucoma following cataract surgery in pediatric patients: a systematic review of incidence, risk factors, and management strategies.BMC ophthalmology · 2026Pooled it
- The outcomes of paediatric cataract surgery with intraocular lens insertion in sub-Saharan Africa: a systematic review.Systematic reviews · 2024Pooled it
- Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review.Scientific reports · 2021Pooled it
- Prevalence of Primary Angle Closure Glaucoma in the Last 20 Years: A Meta-Analysis and Systematic Review.Frontiers in medicine · 2020Pooled it
- Pooled it
- Dynamics of Anterior Chamber Angle Parameters in Primary and Secondary Pseudophakic Eyes Following Congenital Cataract Surgery.Translational vision science & technology · 2026Article
- [Pediatric cataract-part 2 : Surgical treatment].Die Ophthalmologie · 2025Review
- Primary Intraocular Lens Insertion in Infants Under 6 Months of Age: A Retrospective Cohort Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Primary versus secondary intraocular lens implantation following removal of congenital/de al of congenital/developmental catar elopmental cataracts: outcomes after acts: outcomes after at least 4 years.Turkish journal of medical sciences · 2023Article
- Prevalence of Glaucoma Following Paediatric Cataract Surgery in an Australian Tertiary Referral Centre.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Glaucoma and risk factors three years after congenital cataract surgery.BMC ophthalmology · 2022Article
- NovelCold Spring Harbor molecular case studies · 2022Article
- The impact of late-treated pediatric cataract on intraocular pressure.International ophthalmology · 2021Article
- Long-term outcome of primary intraocular lens implantation in bilateral congenital cataract in infants with a median age of 35 days at surgery: a case series.BMJ open ophthalmology · 2021Article
- Congenital Cataract Surgery: A Retrospective Analysis of 62 Patients in a Developing Country.Computational and mathematical methods in medicine · 2021Article
- Commentary review: challenges of intraocular lens implantation for congenital cataract infants.International journal of ophthalmology · 2021Review
- School-based epidemiology study of myopia in Tianjin, China.International ophthalmology · 2020Article
- [Timing of congenital cataract surgery : Amblyopia versus aphakic glaucoma].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Review
- Update on pediatric cataract surgery.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Review
- Surgical outcomes of primary intraocular lens implantation for the treatment of aphakia in pediatric cataracts in the Brazilian public health system.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis meta-analysis aims to evaluate the incidence of secondary glaucoma in patients under the age of 2 years who underwent congenital cataract surgery with or without primary intraocular lens (IOL) implantation.
methodsAn electronic literature search was performed in Medline, EMBASE, and Web of Science databases to retrieve studies between January 2011 and November 2018. Patients with congenital cataract who did primary IOL implantation, aphakia, or secondary IOL implantation followed by receiving extraction surgery were included in this study. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. Long-term incidences of secondary glaucoma, which developed at least one year after cataract surgery, were considered and discussed as clinical outcomes in each cohort. The pooled data were analyzed according to a random effects model.
resultsEight publications involving 892 eyes were included in the current meta-analysis. In the general population of eyes with congenital cataract, the long-term incidence of secondary glaucoma was lower (P = 0.06) in eyes with primary IOL (9.5%) than in eyes without primary IOL (15.1%), including aphakia and secondary IOL. The pooled risk ratio (RR) favors primary IOL implantation in all patients (RR = 0.63). For bilateral congenital cataract, the incidence was 6.7% in eyes with primary IOL implantation, which is significantly lower than the 16.7% in eyes with aphakia and secondary IOL implantation (P<0.05, RR = 0.44). However, for unilateral congenital cataract surgery, the incidence was very similar in eyes with and without primary IOL (12.4% vs 12.0%, P = 0.61, RR = 0.87).
conclusionsIn patients under 2 years of age, primary IOL implantation for bilateral congenital cataract surgery is associated with a lower risk of secondary glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.