Evidence map›Paper›PMID 30933894›Full record

ReviewCurrent opinion in psychology2019

Gene regulation and the architecture of complex human traits in the genomics era.

Brian B Boutwell, Michael A White

Abstract readReview
In one paragraph

Review in Current opinion in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian B BoutwellCriminology and Criminal Justice, Saint Louis University, 3550 Lindell Blvd., St. Louis, MO 63013, United States. Electronic address: brian.boutwell@slu.edu.
Michael A WhiteDepartment of Genetics and Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis School of Medicine, Couch Biomedical Research Building, St. Louis, MO 63110, United States.

Funding

DISCOVERY OF DNA DETERMINANTS OF TRANSCRIPTION FACTOR BINDING AND FUNCTION IN PHOR01GM121755 · NIGMS · WASHINGTON UNIVERSITY · PI WHITE, MICHAEL AARON · 2017 to 2021
$1.5M
CIS-REGULATORY MECHANISMS UNDERLYING RETINOPATHYR01EY027784 · NEI · WASHINGTON UNIVERSITY · PI CHEN, SHIMING, COHEN, BARAK A · 2017 to 2020
$1.4M
Single cell tagging of localized RNA from whole populationsR21GM126307 · NIGMS · WASHINGTON UNIVERSITY · PI STORMO, GARY D · 2018 to 2019
$419k
NEI NIH HHS R01 EY027784NIGMS NIH HHS R01 GM121755NIGMS NIH HHS R21 GM126307
6 · The paper itself

Abstract

Virtually all human psychological and behavioral traits are at least partially heritable. For nearly a century, classical genetic studies have sought to understand how genetic variation contributes to human variation in these traits. More recently, genome-wide association studies have identified large numbers of specific genetic variants linked with complex traits. Many of these variants fall outside of protein-coding genes, in putative gene regulatory elements. This suggests that some fraction of causal human genetic variation acts through gene regulation. New developments in the field of regulatory genomics offer resources and methods to understand how genetic variants that alter gene expression contribute to human psychology and risk for psychiatric disease.

Indexed as

Genome-Wide Association StudyGenomicsGene Regulatory NetworksHumansMultifactorial InheritancePhenotype

Identifiers

PMID30933894
PMCPMC10868639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.