Evidence map›Paper›PMID 30933722›Full record

ArticleStem cell research2019

An induced pluripotent stem cell line (TRNDi006-A) from a MPS IIIB patient carrying homozygous mutation of p.Glu153Lys in the NAGLU gene.

Wei Huang, Miao Xu, Rong Li, Amanda Baskfield, Jennifer Kouznetsova, Jeanette Beers, Jizhong Zou, Chengyu Liu, Wei Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wei HuangNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address: wei.huang@nih.gov.
Miao XuNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address: miao.xu@nih.gov.
Rong LiNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address: rong.li@nih.gov.
Amanda BaskfieldNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address: amanda.baskfield@nih.gov.
Jennifer KouznetsovaNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address: jennifer.kouznetsova@nih.gov.
Jeanette BeersiPSC core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: jeanette.beers@nih.gov.
Jizhong ZouiPSC core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: jizhong.zou@nih.gov.
Chengyu LiuTransgenic Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: Chengyu.liu@nih.gov.
Wei ZhengNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address: wei.zheng@nih.gov.
National Institutes of Health · USNational Center for Advancing Translational Sciences · US

Funding

Transgenic CoreZICHL005907 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LIU, CHENGYU · 2010 to 2025
$25.8M
Drug Repurposing Screening for Rare and Neglected DiseasesZIATR000018 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI ZHENG, WEI · 2015 to 2025
$24.6M
NHLBI iPSC Core FacilityZICHL006145 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZOU, JIZHONG · 2012 to 2025
$23.3M
Intramural NIH HHS ZIA TR000018
6 · The paper itself

Abstract

Mucopolysaccharidosis type III B (MPS IIIB) is a lysosomal storage disorder caused by mutations in the NAGLU gene encoding N-acetylglucosaminidase. Here, we report the generation of a human induced pluripotent stem cell (iPSC) line from dermal fibroblasts of a MPS IIIB patient. The iPSC line has homozygous mutations of G>A transversion at nucleotide 457 of the NAGLU gene (457G>A), resulting in the substitution of lysine for glutamic acid at codon 153 (Glu153Lys). This iPSC line allows for the study of disease phenotypes and pathophysiology as well as disease modeling in human cells.

Indexed as

HomozygoteMutationAcetylglucosaminidaseAnimalsCells, CulturedFemaleFibroblastsHumansInduced Pluripotent Stem CellsInfantMiceMice, Inbred NODMice, SCIDMucopolysaccharidosis IIIPhenotypeTeratomaAcetylglucosaminidasealpha-N-acetyl-D-glucosaminidase

Identifiers

PMID30933722
PMCPMC6559735
OpenAlexW2924238743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.