Evidence map›Paper›PMID 30933707›Full record

ArticleBrain and cognition2019

Reinforcer pathology: Common neural substrates for delay discounting and snack purchasing in prediabetics.

Harshawardhan U Deshpande, Alexandra M Mellis, Jonathan M Lisinski, Jeffrey S Stein, Mikhail N Koffarnus, Rocco Paluch, Ferdinand Schweser, Robert Zivadinov, Stephen M LaConte, Leonard H Epstein and 1 more

Abstract read
In one paragraph

Article in Brain and cognition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. A Reinforcer Pathology perspective on relapse.Journal of the experimental analysis of behavior · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Harshawardhan U DeshpandeFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Alexandra M MellisFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Jonathan M LisinskiFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Jeffrey S SteinFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Mikhail N KoffarnusFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Rocco PaluchUniversity at Buffalo, State University of New York, Buffalo, NY, USA.
Ferdinand SchweserBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.
Robert ZivadinovBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.
Stephen M LaConteFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Leonard H EpsteinUniversity at Buffalo, State University of New York, Buffalo, NY, USA.
Warren K BickelFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA. Electronic address: wkbickel@vtc.vt.edu.

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Delay discounting as a target for self-regulation in prediabetesUH2DK109543 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BICKEL, WARREN K, EPSTEIN, LEONARD H · 2015 to 2017
$2.4M
Delay discounting as a target for self-regulation in prediabetesUH3DK109543 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BICKEL, WARREN K, EPSTEIN, LEONARD H · 2018 to 2019
$2.0M
NCATS NIH HHS UL1 TR001412NIDDK NIH HHS UH2 DK109543NIDDK NIH HHS UH3 DK109543
6 · The paper itself

Abstract

Reinforcer pathology theory stipulates that individuals with both (a) high preference for smaller, immediate over larger, delayed rewards; and (b) high demand for unhealthy commodities are uniquely susceptible to poor health outcomes. Specifically, two behavioral economic tasks (delay discounting, assessing preference for smaller, immediate or larger, delayed rewards; and purchasing, assessing purchases of commodities over changes in price) have been independently associated with conditions such as overweight/obesity and problem substance use. In the present study, we examined possible shared neural regions involved in the processes of delay discounting and demand for snack foods in a prediabetic sample. Fifty-four participants completed both of these tasks. Conjunction between delay discounting and purchasing task results indicates substantial common neural substrates recruited during these two tasks, consistent with interpretations of executive control, interoception, and attention, in the prefrontal cortex, insula, and frontoparietal cortex (superior/middle frontal cortex and superior/inferior parietal lobules), respectively. Collectively, these results suggest possible neural substrates in which the two behavioral risk factors of reinforcer pathology may interact during real-world decision-making in prediabetes.

Indexed as

Decision MakingDelay DiscountingExecutive FunctionAdultAttentionBrainFemaleFunctional NeuroimagingHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMiddle AgedParietal LobePrediabetic StatePrefrontal CortexDelay discountingImpulsivityPrediabetesPurchasingReinforcer pathology

Identifiers

PMID30933707
PMCPMC6626634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.