ArticleHead & neck2019
Organ preservation for patients with anterior mucosal squamous cell carcinoma of the nasal cavity: Rhinectomy-free survival in those refusing surgery.
Article in Head & neck, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Carbon ion radiation therapy for sinonasal malignancies: Promising results from 2282 cases from the real world.Cancer science · 2020Pooled it
- Development and validation of a prognostic model for nasal cavity squamous cell carcinoma based on the SEER database.Scientific reports · 2025Article
- Reconstructive Options after Oncological Rhinectomy: State of the Art.Healthcare (Basel, Switzerland) · 2023Review
- Outcomes Associated with Nasal Reconstruction Post-Rhinectomy: A Narrative Review.Archives of plastic surgery · 2022Article
- Review
- Proton beam therapy of periorbital sinonasal squamous cell carcinoma: Two case reports and review of literature.World journal of clinical oncology · 2020Article
- Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStandard treatment of squamous cell carcinoma (SCC) of the anterior nasal mucosa is surgical resection with or without postoperative radiation.
methodsRetrospective review of patients diagnosed with SCC of the nasal cavity between January 2000 and July 2018 who refused total rhinectomy and who were treated with radiation with or without chemotherapy with curative intent.
resultsEleven patients were identified, 73% had stage III or stage IV disease. Four patients were treated with intensity-modulated radiotherapy and seven with intensity-modulated proton radiotherapy. Concurrent chemoradiotherapy was used in nine patients (82%). With a median follow-up of 15 months (3-124 months), two patients experienced recurrence and one developed distant metastasis and died from disease. The 2-year rhinectomy-free survival rate was 88%. Two-year overall survival and recurrence-free survival were 100% and 75%, respectively.
conclusionA radiation-based approach for SCC of the nasal cavity mucosa is a valid option for selected patients who refuse up-front surgery.
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Registered trials
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