Evidence map›Paper›PMID 30933284›Full record

Observational studyPain medicine (Malden, Mass.)2020

Integrating Adjuvant Analgesics into Perioperative Pain Practice: Results from an Academic Medical Center.

Kuo-Kai Chin, Ian Carroll, Karishma Desai, Steven Asch, Tina Seto, Kathryn M McDonald, Catherine Curtin, Tina Hernandez-Boussard

Registry-linked trialOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pain medicine (Malden, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04705480 (Pregabalin vs. Gabapentin on Reducing Opioid Usage in Trauma Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04705480 phase4completednot on this mapstarted 2021, after this paper: background citation

Pregabalin vs. Gabapentin on Reducing Opioid Usage in Trauma Patients

TypeinterventionalSponsorCAMC Health SystemRan2021 to 2024Enrolled109ConditionsAnalgesics, Gabapentin, Injuries, NarcoticsArmsPregabalin 50mg, Gabapentin 300mg, Neither Pregabalin nor Gabapentin
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Leveraging Digital Data to Inform and Improve Quality Cancer Care.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  4. Reduction of opioid use after orthopedic surgery: a scoping review.Canadian journal of surgery. Journal canadien de chirurgie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kuo-Kai ChinSchool of Medicine, Stanford University.
Ian CarrollDepartment of Medicine, Stanford University, Stanford, CA USA.
Karishma DesaiDepartment of Medicine, Stanford University, Stanford, CA USA.
Steven AschDepartment of Medicine, Stanford University, Stanford, CA USA.
Tina SetoStanford School of Medicine IRT Research Technology, Stanford, CA USA.
Kathryn M McDonaldDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA USA.
Catherine CurtinDepartment of Surgery, VA Palo Alto Health Care System, Palo Alto, CA.
Tina Hernandez-BoussardDepartment of Medicine, Stanford University, Stanford, CA USA.
Stanford University · USVA Palo Alto Health Care System · USStanford Medicine · US

Funding

Advancing Knowledge Discovery for Postoperative Pain ManagementR01LM013362 · NLM · STANFORD UNIVERSITY · PI HERNANDEZ-BOUSSARD, TINA · 2019 to 2023
$3.2M
Improving Quality of postoperative pain care through innovative use of electronic health recordsR01HS024096 · AHRQ · STANFORD UNIVERSITY · PI HERNANDEZ-BOUSSARD, TINA · 2015 to 2019
$1.1M
AHRQ HHS R01 HS024096NLM NIH HHS R01 LM013362
6 · The paper itself

Abstract

backgroundOpioid-sparing postoperative pain management therapies are important considering the opioid epidemic. Total knee arthroplasty (TKA) is a common and painful procedure accounting for a large number of opioid prescriptions. Adjuvant analgesics, nonopioid drugs with primary indications other than pain, have shown beneficial pain management and opioid-sparing effects following TKA in clinical trials. We evaluated the adjuvant analgesic gabapentin for its usage patterns and its effects on opioid use, pain, and readmissions.

methodsThis retrospective, observational study included 4,046 patients who received primary TKA between 2009 and 2017 using electronic health records from an academic tertiary care medical institute. Descriptive statistics and multivariate modeling were used to estimate associations between inpatient gabapentin use and adverse pain outcomes as well as inpatient oral morphine equivalents per day (OME).

resultsOverall, there was an 8.72% annual increase in gabapentin use (P < 0.001). Modeled estimates suggest that gabapentin is associated with a significant decrease in opioid consumption (estimate = 0.63, 95% confidence interval = 0.49-0.82, P < 0.001) when controlling for patient characteristics. Patients receiving gabapentin had similar discharge pain scores, follow-up pain scores, and 30-day unplanned readmission rates compared with patients receiving no adjuvant analgesics (P > 0.05).

conclusionsWhen assessed in a real-world setting over a large cohort of TKA patients, gabapentin is an effective pain management therapy that is associated with reduced opioid consumption-a national priority in this time of opioid crisis-while maintaining the same quality of pain management.

Indexed as

AdultAgedAnalgesics, Non-NarcoticAnalgesics, OpioidArthroplasty, Replacement, KneeCohort StudiesFemaleGabapentinHumansMaleMiddle AgedPain ManagementPostoperative PainRetrospective StudiesAnalgesics, Non-NarcoticAnalgesics, OpioidGabapentinadjuvant analgesicGabapentinknee arthroplastyopioid-sparing

Identifiers

PMID30933284
PMCPMC10147384
OpenAlexW2934881426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.