ArticleAIDS (London, England)2019
Hearing complaints in HIV infection originate in the brain not the ear.
Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Machine learning for predicting cognitive deficits using auditory and demographic factors.PloS one · 2024Article
- Peripheral Auditory Function in Tanzanian Children Living With HIV With Clinically Normal Hearing.JAMA network open · 2023Article
- Pathophysiology and mechanisms of hearing impairment related to neonatal infection diseases.Frontiers in microbiology · 2023Review
- Peripheral Auditory Function in Young HIV-Positive Adults With Clinically Normal Hearing.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2022Article
- Central Auditory Tests to Track Cognitive Function in People With HIV: Longitudinal Cohort Study.JMIR formative research · 2021Article
- The Relationship Between Central Auditory Tests and Neurocognitive Domains in Adults Living With HIV.Frontiers in neuroscience · 2021Article
- Unexplained multi-sensory neuropathy syndrome in young Tanzanian adults.Journal of global health reports · 2021Article
- Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Main Aspects of Peripheral and Central Hearing System Involvement in Unexplained HIV-Related Hearing Complaints.Frontiers in neurology · 2019Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveEvidence suggests damage to brain auditory pathways, rather than inner ear damage, underlies the hearing difficulties HIV+ individuals report. But, antiretroviral therapy (ART) may affect the hearing system and also lead to hearing complaints.
designLongitudinal study of HIV+ and HIV- individuals in Dar es Salaam Tanzania. A subset of this cohort started ART while in the study allowing the effects of ART to be studied directly.
methodsThe ability to hear quiet sounds (pure-tone audiometry), cochlear outer hair cell function [distortion-product otoacoustic emissions (DPOAEs)], and gaps-in-noise detection thresholds (a central auditory processing test) were assessed at each visit. Visits were scheduled for 6-month intervals, but the number and spacing of visits varied. In the group that started ART while in the study, 107 HIV+ individuals had audiometric thresholds, 98 had DPOAEs, and 98 had gap measurements suitable for analysis. Data were analyzed using a linear mixed model with time and starting ART as fixed effects and individual participant repeated measures as random effects.
resultsStarting ART did not affect audiometric or gap detection thresholds. The slope of the DPOAE amplitude vs. time relationship was more negative after starting ART but did not differ from the HIV- group. Gap thresholds were higher in the HIV+ group.
conclusionART did not affect audiometric thresholds significantly suggesting common ART drugs are not major ototoxins. The gap detection results from the study show effects on central auditory processing in HIV+ individuals, supporting the origin of HIV-related hearing complaints in the central auditory system.
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