Evidence map›Paper›PMID 30932391›Full record

ArticleJournal of epidemiology and global health2019

Pediatric Multidrug-resistant Tuberculosis in Kyiv City, Ukraine.

Silvia Shinpei Chiang, Yana Sheremeta, Rachel Sophie Padilla, Helen Elizabeth Jenkins, Charles Robert Horsburgh, Vasyl Petrenko, Natasha Renee Rybak

Abstract read
In one paragraph

Article in Journal of epidemiology and global health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Tuberculosis: An Epidemic Perpetuated by Health Inequalities.Rhode Island medical journal (2013) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Silvia Shinpei ChiangDepartment of Pediatrics, Alpert Medical School of Brown University, Providence, RI, USA.
Yana SheremetaDepartment of Tuberculosis and Pulmonology, Bogomolets National Medical University, Kyiv, Ukraine.
Rachel Sophie PadillaDepartment of Medicine, The Miriam Hospital, Providence, RI, USA.
Helen Elizabeth JenkinsDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Charles Robert HorsburghDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Vasyl PetrenkoDepartment of Tuberculosis and Pulmonology, Bogomolets National Medical University, Kyiv, Ukraine.
Natasha Renee RybakDepartment of Medicine, The Miriam Hospital, Providence, RI, USA.

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Validation and Application of a Model for Human-like TB Latency in RabbitsU19AI111276 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, HORN, DAVID LOUIS · 2014 to 2020
$23.3M
Brown NIMHD Minority Health & Health Disparities International Research TrainingT37MD008655 · NIMHD · BROWN UNIVERSITY · PI FLANIGAN, TIMOTHY P · 2014 to 2018
$1.2M
Teens on TB Treatment: Predicting Adherence through Clinical Decision AnalysisK01TW010829 · FIC · RHODE ISLAND HOSPITAL · PI CHIANG, SILVIA SHINPEI · 2017 to 2021
$775k
Understanding spatial heterogeneity of drug resistant tuberculosisK01AI102944 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI JENKINS, HELEN E. · 2013 to 2017
$627k
FIC NIH HHS K01 TW010829NIAID NIH HHS L40 AI141492
6 · The paper itself

Abstract

Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite the fact that these countries have the highest proportion of TB cases that are MDR. We aimed to examine pediatric MDR-TB in Ukraine. This retrospective cohort study included all children <18 years of age who started undergoing MDR-TB treatment between January 1, 2011 and July 31, 2016 at Kyiv City Pediatric TB Hospital. From each child's clinical chart, we abstracted demographic and clinical data. Using Fisher's exact test, we compared characteristics between children with microbiologically confirmed vs. probable (i.e., clinically diagnosed) MDR-TB. The study population included 20 children with a median age of 5 years. At diagnosis, 12 (60%) had intrathoracic lymphadenopathy as their only radiographic abnormality, and two (10%) were asymptomatic. Children with confirmed MDR-TB were more likely to be adolescents or have radiologic abnormalities in addition to intrathoracic lymphadenopathy. Median treatment duration was 20 months. Eighteen (90%) children were treated successfully. The remaining two were transferred to another facility, and their final outcomes were unknown. The excellent outcomes in this cohort are consistent with high treatment success rates for pediatric MDR-TB reported in other parts of the world.

Indexed as

AdolescentAntitubercular AgentsChildChild, PreschoolFemaleHumansMaleMycobacterium tuberculosisRetrospective StudiesTuberculosis, Multidrug-ResistantUkraineAntitubercular AgentsadolescentchildrenMultidrug-resistant tuberculosisUkraine

Identifiers

PMID30932391
PMCPMC7024600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.