Evidence map›Paper›PMID 30932360›Full record

Trial reportArthritis care & research2020

Early Magnetic Resonance Imaging-Based Changes in Patients With Meniscal Tear and Osteoarthritis: Eighteen-Month Data From a Randomized Controlled Trial of Arthroscopic Partial Meniscectomy Versus Physical Therapy.

Jamie E Collins, Elena Losina, Robert G Marx, Ali Guermazi, Mohamed Jarraya, Morgan H Jones, Bruce A Levy, Lisa A Mandl, Scott D Martin, Rick W Wright and 3 more

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Arthritis care & research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00597012 (Partial Meniscectomy Versus Nonoperative Management in Meniscal Tear With OA), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00597012 nacompletednot on this map

Partial Meniscectomy Versus Nonoperative Management in Meniscal Tear With OA: A Randomized Controlled Trial (MeTeOR)

TypeinterventionalSponsorBrigham and Women's HospitalRan2008 to 2025Enrolled351ConditionsOsteoarthritisArmsArthroscopic partial menisectomy, Standard physical therapy, Postoperative rehabilitative physical therapy
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Jamie E CollinsBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8413-007X
Elena LosinaBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-3424-0892
Robert G MarxWeill Cornell Medicine, Hospital for Special Surgery, New York, New York.
Ali GuermaziBoston University School of Medicine, Boston, Massachusetts.
Mohamed JarrayaBoston University School of Medicine, Boston, Massachusetts, and Mercy Catholic Medical Center, Darby, Pennsylvania.
Morgan H JonesCleveland Clinic, Cleveland, Ohio.
Bruce A LevyMayo Clinic, Rochester, Minnesota.
Lisa A MandlWeill Cornell Medicine, Hospital for Special Surgery, New York, New York.
Scott D MartinMassachusetts General Hospital, Boston.
Rick W WrightWashington University School of Medicine, St. Louis, Missouri.
Kurt P SpindlerCleveland Clinic, Cleveland, Ohio.
Jeffrey N KatzBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
MeTeOR Investigator Group
Brigham and Women's Hospital · USBoston University · USCleveland Clinic · USHospital for Special Surgery · USMassachusetts General Hospital · USMayo Clinic · USWashington University in St. Louis · US

Funding

PARTIAL MENISCECTOMY VS. NONOPERATIVE MGMT. IN MENISCAL TEAR WITH OA: AN RCTR01AR055557 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2007 to 2023
$11.2M
VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Patient Oriented Research and Mentoring Program in OrthopedicsK24AR057827 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2010 to 2019
$1.7M
NIAMS NIH HHS K24 AR057827NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR055557
6 · The paper itself

Abstract

objectiveThe present study was undertaken to evaluate changes in knee magnetic resonance imaging (MRI) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (APM) or nonoperatively with physical therapy (PT).

methodsWe used 18-month follow-up data from the Meniscal Tear in Osteoarthritis Research Trial. MRI results were read with reference to the MRI Osteoarthritis Knee Score. We focused on 18-month change in bone marrow lesions (BMLs), cartilage thickness, cartilage surface area, osteophyte size, effusion-synovitis, and Hoffa-synovitis. We used multinomial logistic regression to assess associations between MRI-based changes in each feature and treatment type.

resultsA total of 351 subjects were randomized, and 225 had both baseline and 18-month MRI results. In both treatment groups, patients experienced substantial changes in several MRI-based markers. In 60% of the APM group, versus 33% of the PT group, cartilage surface area damage advanced in ≥2 subregions (adjusted odds ratio 4.2 [95% confidence interval 2.0-9.0). Patients who underwent APM also had greater advancement in scores for osteophytes and effusion-synovitis. We did not find significant associations between treatment type and change in cartilage thickness, BMLs, or Hoffa-synovitis.

conclusionThis cohort of patients with meniscal tear and osteoarthritis showed marked advancement in MRI-based features over 18 months. Patients treated with APM showed more advancement in some features compared to those treated nonoperatively. The clinical relevance of these early findings is unknown and requires further study.

Indexed as

ArthroscopyMagnetic Resonance ImagingMeniscectomyPhysical Therapy ModalitiesAgedDisease ProgressionFemaleHumansKnee JointMaleMiddle AgedOsteoarthritis, KneePredictive Value of TestsRecovery of FunctionTibial Meniscus InjuriesTime Factors

Identifiers

PMID30932360
PMCPMC6773533
OpenAlexW2933704077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.