Evidence map›Paper›PMID 30932322›Full record

ArticleGenes, brain, and behavior2020

Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.

Kira D A Rienecker, Alexander T Chavasse, Kim Moorwood, Andrew Ward, Anthony R Isles

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Deficiency of the paternally-expressed imprintedFrontiers in neuroscience · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kira D A RieneckerMRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-4014-4709
Alexander T ChavasseMRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, UK.
Kim MoorwoodDepartment of Biology and Biochemistry, University of Bath, Bath, UK.
Andrew WardDepartment of Biology and Biochemistry, University of Bath, Bath, UK.
Anthony R IslesMRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-7587-5712

Funding

Medical Research Council G0801418Medical Research Council MR/L007215/1Medical Research Council MR/L010305/1Medical Research Council MR/S008233/1Wellcome 105218/Z/14/ZWellcome Trust
6 · The paper itself

Abstract

Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10

Indexed as

Social DominanceAnimalsFemaleGene DeletionGRB10 Adaptor ProteinMaleMicePaternal InheritanceSocial IsolationStress, PsychologicalGRB10 Adaptor ProteinGrb10 protein, mouseagebarberinggenomic imprintingsocial dominancesocial isolation

Identifiers

PMID30932322
PMCPMC7050506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.