ArticleAddiction biology2020
Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder.
Article in Addiction biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Handgrip and gait metrics as scalable markers of physical health in schizophrenia and alcohol use disorders.Global mental health (Cambridge, England) · 2026Article
- Recent Investigations Designed to Unravel the Interaction of Age and Alcohol on Behavior and Cognition: Potential Neurobiological Mechanisms.Advances in experimental medicine and biology · 2025Review
- Multi-domain predictors of grip strength differentiate individuals with and without alcohol use disorder.Addiction biology · 2024Article
- Morphological Brain Networks of White Matter: Mapping, Evaluation, Characterization, and Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Alterations of brain activity in patients with alcohol use disorder: a resting-state fMRI study.BMC psychiatry · 2023Article
- Chronic Cocaine Use and White Matter Coherence: A Diffusion Tensor Imaging Study.Journal of studies on alcohol and drugs · 2023Article
- Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia.Alcohol (Fayetteville, N.Y.) · 2023Review
- Alcohol use disorder-associated structural and functional characteristics of the insula.Journal of neuroscience research · 2022Article
- Disruption of cerebellar-cortical functional connectivity predicts balance instability in alcohol use disorder.Drug and alcohol dependence · 2022Article
- Dose-dependent relationship between social drinking and brain aging.Neurobiology of aging · 2022Article
- Longitudinal self-supervised learning.Medical image analysis · 2021Article
- Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Longitudinal Pooling & Consistency Regularization to Model Disease Progression From MRIs.IEEE journal of biomedical and health informatics · 2021Article
- Impact of Alcohol Abuse on Susceptibility to Rare Neurodegenerative Diseases.Frontiers in molecular biosciences · 2021Review
- Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders.Current addiction reports · 2021Review
- Investigating Associations Between Inflammatory Biomarkers, Gray Matter, Neurofilament Light and Cognitive Performance in Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
- The Effect of Chronic Ethanol Exposure and Thiamine Deficiency on Myelin-related Genes in the Cortex and the Cerebellum.Alcoholism, clinical and experimental research · 2020Article
- Multi-modal imaging reveals differential brain volumetric, biochemical, and white matter fiber responsivity to repeated intermittent ethanol vapor exposure in male and female rats.Neuropharmacology · 2020Article
- Disturbed Cerebellar Growth Trajectories in Adolescents Who Initiate Alcohol Drinking.Biological psychiatry · 2020Article
- Brain Structure and Function in Recovery.Alcohol research : current reviews · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathological studies, white matter systems of the cerebellum are vulnerable to chronic alcohol dependence. To pursue the effect of AUD on white matter structure and functions in vivo, this study used T1-weighted, magnetic resonance imaging (MRI) to quantify the total corpus medullare of the cerebellum and a finely grained analysis of its surface in 135 men and women with AUD (mean duration of abstinence, 248 d) and 128 age- and sex-matched control participants; subsets of these participants completed motor testing. We identified an AUD-related volume deficit and accelerated aging in the total corpus medullare. Novel deformation-based surface morphometry revealed regional shrinkage of surfaces adjacent to lobules I-V, lobule IX, and vermian lobule X. In addition, accelerated aging was detected in the regional surface areas adjacent to lobules I-V, lobule VI, lobule VIIB, and lobules VIII, IX, and X. Sex differences were not identified for any measure. For both volume-based and surface-based analyses, poorer performance in gait and balance, manual dexterity, and grip strength were linked to greater regional white matter structural deficits. Our results suggest that local deformation of the corpus medullare has the potential of identifying structurally and functionally segregated networks affected in AUD.
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