ArticleJournal of perinatology : official journal of the California Perinatal Association2019
Dysnatremia in extremely low birth weight infants is associated with multiple adverse outcomes.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Maintenance intravenous fluid therapy in infants with sepsis and hyponatremia: a clinical trial.BMC pediatrics · 2024Trial
- Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Epidemiology of early onset hyponatremia in extremely preterm neonates: A retrospective observational study.Journal of neonatal-perinatal medicine · 2026Observational
- Sodium Values During the First 10 Postnatal Days in Extremely-Low-Birth-Weight Infants and Long-Term Neurocognitive Outcomes: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Hyponatremia in the neonatal intensive care unit: incidence, risk factors and effect on mortality.BMC pediatrics · 2026Article
- Hypernatremia during the first week of life in very preterm infants and neurodevelopmental outcomes at 3 to 4 years of age: a cohort study.BMC pediatrics · 2026Article
- The Changing Landscape of Sodium Needs in the Preterm Neonate for Optimizing Growth and Development.Nutrients · 2026Review
- Early glucose and sodium trajectories and short-term outcomes in extremely preterm infants.Frontiers in pediatrics · 2026Article
- Sodium Patterns and Their Variables in a Cohort of ELBW Infants in the First 10 Days of Life.Children (Basel, Switzerland) · 2025Article
- Hypo- and Hypernatremia in Extremely Low Birth Weight Infants in the First 10 Days of Life: A Review.Children (Basel, Switzerland) · 2025Review
- Thermoregulation, incubator humidity, and skincare practices in appropriate for gestational age ultra-low birth weight infants: need for more evidence.World journal of pediatrics : WJP · 2024Review
- Excessive sodium supplementation but not fluid load is correlated with overall morbidity in extremely low birth weight infants.JPGN reports · 2024Article
- Increasing Sodium Variability in the First 96 Hours after Birth is Associated with Adverse In-Hospital Outcomes of Preterm Newborns.Current developments in nutrition · 2023Article
- Sodium and Growth in Preterm Infants: A Review.Newborn (Clarksville, Md.) · 2023Article
- Neurodevelopmental consequences of early plasma sodium changes in very preterm infants.Pediatric research · 2022Article
- Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Article
- Management of Acute Kidney Injury in Extremely Low Birth Weight Infants.Frontiers in pediatrics · 2022Review
- Hypochloremia Secondary to Diuretics in Preterm Infants: Should Clinicians Pay Close Attention?Global pediatric health · 2021Review
- Maintenance Fluids for Late Preterm and Term Infants: Is it Time to Reconsider?Pediatrics open scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study is to discern patterns of serum sodium in a broad cohort of extremely low birth weight (ELBW) infants and associate those patterns with hospital outcomes. STUDY
designRetrospective cohort study of ELBW infants from 323 neonatal intensive care units (NICUs) discharged from 2004 to 2014. We included patients who survived at least 7 days and had daily sodium levels available, and categorized infants by their minimum and maximum sodium levels.
resultsWe identified 26,871 infants of whom 12,428 met inclusion criteria. Only 1964 (15.8%) maintained eunatremia for the first week. We found most dysnatremias to be associated with increased overall mortality compared with eunatremic patients including moderate hyponatremia (12.9% vs. 8.6%, p < 0.05) and severe hypernatremia (34.8% vs. 8.6%, p < 0.001). Most of these associations were maintained after regression modeling for mortality.
conclusionSodium fluctuations occurring within the first week of life are associated with increased mortality.
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Registered trials
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