ArticleScientific reports2019
Evolutionary expression differences of creatine synthesis-related genes: Implications for skeletal muscle metabolism in fish.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Fuelled by creatine: exploring two copies of the creatine transporter SLC6A8 gene in rainbow trout.Fish physiology and biochemistry · 2026Article
- Metabolites produced by agat+ cells support regeneration in the planarian Schmidtea mediterranea.Developmental biology · 2026Article
- Transcriptomic suppression of immune and ECM stability in skeletal muscle of patients with chronic kidney disease.PloS one · 2026Article
- Blood Biochemical Biomarkers in Fish Toxicology-A Review.Animals : an open access journal from MDPI · 2025Review
- A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impairments.Frontiers in immunology · 2025Article
- Creatine Ameliorates the Adverse Effects of High-Fat Diet on Hepatic Lipid MetabolismAquaculture nutrition · 2025Article
- Review
- Gene ontology defines pre-post- hatch energy dynamics in the complexus muscle of broiler chickens.BMC genomics · 2024Article
- Metabolomic and Lipidomic Tools for Tracing Fish Escapes from Aquaculture Facilities.ACS food science & technology · 2024Article
- Dietary glycine supplementation enhances creatine availability in tissues of pigs with intrauterine growth restriction.Journal of animal science · 2024Article
- First report on the toxicity of SARS-CoV-2, alone and in combination with polyethylene microplastics in neotropical fish.The Science of the total environment · 2023Article
- Comparative Analysis of miRNA-mRNA Regulation in the Testes ofInternational journal of molecular sciences · 2023Article
- Supply and demand of creatine and glycogen in broiler chicken embryos.Frontiers in physiology · 2023Article
- Metabolic Changes During Growth and Reproductive Phases in the Liver of Female Goldfish (Carassius auratus).Frontiers in cell and developmental biology · 2022Article
- Fish Allergenicity Modulation Using Tailored Enriched Diets-Where Are We?Frontiers in physiology · 2022Review
- Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Review
- Proteomic profile and morphological characteristics of skeletal muscle from the fast- and slow-growing yellow perch (Perca flavescens).Scientific reports · 2021Article
- Transcriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis).BMC genomics · 2021Article
- Insights into early ontogenesis: characterization of stress and development key genes of pikeperch (Sander lucioperca) in vivo and in vitro.Fish physiology and biochemistry · 2021Article
- Creatine synthesis in the skeletal muscle: the times they are a-changin'.American journal of physiology. Endocrinology and metabolism · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The creatine/phosphocreatine system is the principal energy buffer in mammals, but is scarcely documented in fish. We measured the gene expression of major enzymes of this system, glycine amidinotransferase (GATM), guanidinoacetate N-methyltransferase (GAMT) and muscle-type creatine kinase (CKM) in kidney, liver, and muscle tissues of fish and mammals. CKM was expressed strongly in the muscles of all examined species. In contrast, GATM and GAMT were strongly expressed in the muscle tissue of fish, but not of mammals. This indicates that creatine synthesis and usage are spatially separated in mammals, but not in fish, which is supported by RNA-Seq data of 25 species. Differences in amino acid metabolism along with methionine adenosyltransferase gene expression in muscle from fishes but not mammals further support a central metabolic role of muscle in fish, and hence different organization of the creatine/phosphocreatine biosynthesis system in higher and lower vertebrates.
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