Evidence map›Paper›PMID 30931988›Full record

ArticleScientific reports2019

The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5.

Zakia A Abdelhamed, Dina I Abdelmottaleb, Mohammed E El-Asrag, Subaashini Natarajan, Gabrielle Wheway, Chris F Inglehearn, Carmel Toomes, Colin A Johnson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. The meningeal-cerebellar axis: a new perspective on cerebellar development.Cellular and molecular life sciences : CMLS · 2025
    Review
  2. Article
  3. Article
  4. Neuronal guidance behaviours: the primary cilium perspective.Frontiers in cell and developmental biology · 2025
    Review
  5. Review
  6. Review
  7. Kinase Inhibitors in Genetic Diseases.International journal of molecular sciences · 2023
    Review
  8. The Joubert-Meckel-Nephronophthisis Spectrum of Ciliopathies.Annual review of genomics and human genetics · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Zakia A AbdelhamedDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK.
Dina I AbdelmottalebDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK.
Mohammed E El-AsragDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK.ORCID http://orcid.org/0000-0003-3750-7414
Subaashini NatarajanDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK.
Gabrielle WhewayHuman Development and Health, Faculty of Medicine, University of Southampton, SO16 6YD, Southampton, UK.ORCID http://orcid.org/0000-0002-0494-0783
Chris F InglehearnDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK.
Carmel ToomesDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK.
Colin A JohnsonDivison of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, LS9 7TF, Leeds, UK. c.johnson@leeds.ac.uk.ORCID http://orcid.org/0000-0002-2979-8234
University of Leeds · GBCincinnati Children's Hospital Medical Center · USUniversity of Southampton · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P007791/1Medical Research Council G0700073Medical Research Council MR/M000532/1Wellcome TrustWellcome Trust ME041596
6 · The paper itself

Abstract

Primary cilia defects result in a group of related pleiotropic malformation syndromes known as ciliopathies, often characterised by cerebellar developmental and foliation defects. Here, we describe the cerebellar anatomical and signalling defects in the Tmem67

Indexed as

Wnt Signaling PathwayAnimalsbeta CateninCells, CulturedCerebellumCiliaHomeodomain ProteinsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutSignal Transductionbeta CateninHomeodomain ProteinsHoxb5 protein, mouseMembrane ProteinsTMEM67 protein, mouse

Identifiers

PMID30931988
PMCPMC6445493
OpenAlexW2928892233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.