Evidence map›Paper›PMID 30931962›Full record

ArticleScientific reports2019

Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer.

Tomoko Ozeki, Mitsuji Nagahama, Kazuma Fujita, Akifumi Suzuki, Kiminori Sugino, Koichi Ito, Masatomo Miura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tomoko OzekiDepartment of Pharmacy, Akita University Hospital, Akita, Japan.
Mitsuji NagahamaDepartment of Surgery, Ito Hospital, Tokyo, Japan.
Kazuma FujitaDepartment of Pharmacy, Akita University Hospital, Akita, Japan.
Akifumi SuzukiDepartment of Surgery, Ito Hospital, Tokyo, Japan.
Kiminori SuginoDepartment of Surgery, Ito Hospital, Tokyo, Japan.
Koichi ItoDepartment of Surgery, Ito Hospital, Tokyo, Japan.
Masatomo MiuraDepartment of Pharmacy, Akita University Hospital, Akita, Japan. m-miura@hos.akita-u.ac.jp.
Ito Hospital · JPAkita University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lenvatinib is a substrate of cytochrome P450 (CYP) 3A and ATP-binding cassette (ABC) transporters. In this study, we aimed to evaluate how CYP3A4/5 and ABC transporter polymorphisms affected the mean steady-state dose-adjusted plasma trough concentrations (C

Indexed as

Polymorphism, Single NucleotideAdultAgedAllelesAsian PeopleATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2Cytochrome P-450 CYP3AFemaleGene FrequencyGenotypeHumansJapanMaleMiddle AgedMultidrug Resistance-Associated Protein 2ABCB1 protein, humanABCC2 protein, humanATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2Cytochrome P-450 CYP3AlenvatinibMultidrug Resistance-Associated Protein 2Phenylurea CompoundsProtein Kinase InhibitorsQuinolines

Identifiers

PMID30931962
PMCPMC6443943
OpenAlexW2933549012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.