ArticleNature communications2019
Cortical recruitment determines learning dynamics and strategy.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- EthoPy provides an accessible platform for reproducible behavioral neuroscience.Cell reports methods · 2026Article
- Article
- Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice.Nature communications · 2026Article
- Sound feature representations decorrelate across the mouse auditory pathway.PLoS biology · 2025Article
- A spatial code for temporal information is necessary for efficient sensory learning.Science advances · 2025Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- All-optical interrogation of neural circuits in behaving mice.Nature protocols · 2022Review
- Experienced entropy drives choice behavior in a boring decision-making task.Scientific reports · 2022Article
- Deep imaging in the brainstem reveals functional heterogeneity in V2a neurons controlling locomotion.Science advances · 2020Article
- Article
- Engrams of Fast Learning.Frontiers in cellular neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salience is a broad and widely used concept in neuroscience whose neuronal correlates, however, remain elusive. In behavioral conditioning, salience is used to explain various effects, such as stimulus overshadowing, and refers to how fast and strongly a stimulus can be associated with a conditioned event. Here, we identify sounds of equal intensity and perceptual detectability, which due to their spectro-temporal content recruit different levels of population activity in mouse auditory cortex. When using these sounds as cues in a Go/NoGo discrimination task, the degree of cortical recruitment matches the salience parameter of a reinforcement learning model used to analyze learning speed. We test an essential prediction of this model by training mice to discriminate light-sculpted optogenetic activity patterns in auditory cortex, and verify that cortical recruitment causally determines association or overshadowing of the stimulus components. This demonstrates that cortical recruitment underlies major aspects of stimulus salience during reinforcement learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.