Evidence map›Paper›PMID 30931481›Full record

ArticleMolecular human reproduction2019

Emerging concepts of shear stress in placental development and function.

L C Morley, D J Beech, J J Walker, N A B Simpson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular human reproduction, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  16. MatriGridBioengineering (Basel, Switzerland) · 2022
    Review
  17. Article
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  20. Go with the Flow-Trophoblasts in Flow Culture.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

L C MorleyLeeds Institute of Cardiovascular and Metabolic Medicine, LIGHT Laboratories, University of Leeds, UK.
D J BeechLeeds Institute of Cardiovascular and Metabolic Medicine, LIGHT Laboratories, University of Leeds, UK.
J J WalkerAcademic department of Obstetrics and Gynaecology, Level, Worsley Building, University of Leeds, UK.
N A B SimpsonAcademic department of Obstetrics and Gynaecology, Level, Worsley Building, University of Leeds, UK.
University of Leeds · GB

Funding

British Heart Foundation RG/17/11/33042Medical Research Council MR/P002099/1Wellcome Trust
6 · The paper itself

Abstract

Blood flow, and the force it generates, is critical to placental development and function throughout pregnancy. This mechanical stimulation of cells by the friction generated from flow is called shear stress (SS) and is a fundamental determinant of vascular homeostasis, regulating remodelling and vasomotor tone. This review describes how SS is fundamental to the establishment and regulation of the blood flow through the uteroplacental and fetoplacental circulations. Amongst the most recent findings is that alongside the endothelium, embryonic stem cells and the villous trophoblast are mechanically sensitive. A complex balance of forces is required to enable effective establishment of the uteroplacental circulation, while protecting the embryo and placental villi. SS also generates flow-mediated vasodilatation through the release of endothelial nitric oxide, a process vital for adequate placental blood flow. The identification of SS sensors and the mechanisms governing how the force is converted into biochemical signals is a fast-paced area of research, with multiple cellular components under investigation. For example, the Piezo1 ion channel is mechanosensitive in a variety of tissues including the fetoplacental endothelium. Enhanced Piezo1 activity has been demonstrated in response to the Yoda1 agonist molecule, suggesting the possibility for developing tools to manipulate these channels. Whether such agents might progress to novel therapeutics to improve blood flow through the placenta requires further consideration and research.

Indexed as

Endothelial CellsFemaleHumansMechanotransduction, CellularPlacentaPlacentationPregnancyStress, Mechanicalendothelial cellsmechanosensingPiezo1placentashear stress

Identifiers

PMID30931481
PMCPMC6554190
OpenAlexW2928471418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.