ArticleCurrent developments in nutrition2019
The Associations of Maternal and Neonatal Vitamin D with Dental Development in Childhood.
Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Influence of Vitamin D on Developmental Defects of Enamel (DDE) in Children and Adolescents: A Systematic Review.Nutrients · 2025Pooled it
- Examining the Role of Vitamin D in Caries Susceptibility in Children's Deciduous Teeth: A Systematic Review.Nutrients · 2023Pooled it
- An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review.Nutrients · 2023Pooled it
- Association between maternal serum levels of Alpha-Fetoprotein and eruption timing of the first central deciduous tooth: a cross-sectional study.The Saudi dental journal · 2025Article
- Association of prenatal vitamin D concentration with the eruption time of the first primary tooth: A prospective cohort study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Prenatal maternal salivary hormones and timing of tooth eruption in early childhood: a prospective birth cohort study.Frontiers in oral health · 2025Article
- Evaluation of serum levels in children with delayed eruption.BMC oral health · 2024Article
- Oral and craniofacial research in the Generation R study: an executive summary.Clinical oral investigations · 2023Article
- Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children.Nutrients · 2021Article
- Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding.Nutrients · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D influences the formation and mineralization of teeth.
objectiveTo investigate the association of maternal and neonatal vitamin D concentrations with the dental development of 10-y-old children, in a population-based prospective cohort study among 3,770 mothers and children in the Netherlands.
methodsMaternal venous blood samples were collected in the second trimester (median 20.4 weeks of gestation; range: 18.5-23.2 wk) whereas umbilical cord blood samples were collected immediately after delivery (median 40.1 weeks of gestation; range 35.9-42.3 wk). Dental development was defined using the Demirjian method. Multivariate regression models were built to analyze the studied associations.
resultsHigh concentrations of 25-hydroxyvitamin D [25(OH)D] during midpregnancy (β: -0.04; 95% CI: -0.08, -0.01) and at birth (β: -0.06; 95% CI: -0.10, -0.02) were associated with a lower dental age in children. The children of mothers with severe vitamin D deficiency [25(OH)D <25.0 nmol/L] during midpregnancy exhibited a higher dental age (β: 0.14; 95% CI: 0.03, 0.24) and higher developmental stages of the mandibular first premolar (β: 0.32; 95% CI: 0.04, 0.60) compared with the children of mothers with optimal values of 25(OH)D (≥75.0 nmol/L). Children with vitamin D deficiency [25(OH)D 25.0-49.9 nmol/L] at birth exhibited a higher dental age (β: 0.11; 95% CI: 0.01, 0.20), higher developmental stages of the mandibular second premolar (β: 0.27; 95% CI: 0.02, 0.51), and higher developmental stages of the mandibular second molar (β: 0.24; 95% CI: 0.00, 0.48) compared with children with sufficient-to-optimal values of 25(OH)D (≥50.0 nmol/L) at birth.
conclusionHigher maternal and neonatal 25(OH)D concentrations are associated with decelerated dental development in childhood. The lower the vitamin D level during midpregnancy or at birth, the higher the dental age of children, and the higher the developmental stages of the mandibular teeth.
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