Evidence map›Paper›PMID 30931423›Full record

ArticleJournal of the Endocrine Society2019

Pubertal Lipid Levels Are Significantly Lower in Youth With Type 1 Diabetes Who Experienced Partial Clinical Remission.

Benjamin Udoka Nwosu, Shwetha Rupendu, Emily Zitek-Morrison, Deepa Patel, Tony R Villalobos-Ortiz, Gabrielle Jasmin, Bruce A Barton

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes.Journal of pediatric endocrinology & metabolism : JPEM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Benjamin Udoka NwosuDivision of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts.ORCID 0000-0003-2212-0276
Shwetha RupenduDivision of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts.
Emily Zitek-MorrisonDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts.
Deepa PatelDivision of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts.
Tony R Villalobos-OrtizDivision of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts.
Gabrielle JasminDivision of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts.
Bruce A BartonDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts.
University of Massachusetts Chan Medical School · US

Funding

Vitamin D and Residual Beta-Cell Function in Type 1 DiabetesR21DK113353 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI NWOSU, BENJAMIN UDOKA · 2017 to 2019
$628k
NIDDK NIH HHS R21 DK113353
6 · The paper itself

Abstract

importanceThe physiologic changes in lipids during puberty in type 1 diabetes (T1D) are unclear because subjects in previous studies were not stratified by partial clinical remission status.

aimTo determine the effect of partial clinical remission on lipid changes during puberty in youth with T1D. SUBJECTS AND

methodsA retrospective cross-sectional study of 194 subjects consisting of 71 control subjects of age 12.9 ± 1.3 years and 123 subjects with T1D stratified into remitters (n = 44; age, 13.0 ± 0.8 years) and nonremitters (n = 79; age, 11.2 ± 0.6 years). Partial clinical remission was defined as insulin-dose adjusted HbA1c of ≤9. Pubertal status was determined by Tanner staging.

resultsAmong the pubertal cohort, low-density lipoprotein cholesterol concentration was significantly higher in the nonremitters compared with remitters (91.1 ± 25.6 vs 77.2 ± 25.8 mg/dL,

conclusionsPuberty-related reductions in low-density lipoprotein, total cholesterol, and non-high-density lipoprotein occur in remitters and normal-weight control subjects but not in nonremitters and overweight/obese control subjects.

Indexed as

cardiovascular disease riskchildrendyslipidemiahoneymoon phasepartial clinical remissiontype 1 diabetes

Identifiers

PMID30931423
PMCPMC6436764
OpenAlexW2915142519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.