Evidence map›Paper›PMID 30931337›Full record

ArticleInternational journal of advanced research2018

TLT-1-CONTROLS EARLY THROMBUS FORMATION AND STABILITY BY FACILITATING AIIBB3 OUTSIDE-IN SIGNALING IN MICE.

Morales-Ortíz Jessica, Reyes Fiorella, Santiago Ocatavio, Rivera Linnette, Ledesma Nahomy, Manne B Kanth, Madera Bismarck, Matthew T Rondina, Washington A Valance

Open access · hybridAbstract read
In one paragraph

Article in International journal of advanced research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability.International journal of molecular sciences · 2022
    Review
  5. Genome-Wide Association Study forPathogens (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Article
  8. Review
  9. Platelet biology of the rapidly failing lung.British journal of haematology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Morales-Ortíz JessicaUniversity of Puerto Rico-Rio Piedras, Department of Biology.
Reyes FiorellaLaboratory of Anatomy and Cell Biology, Universidad Central del Caribe, Bayamón PR.
Santiago OcatavioLaboratory of Anatomy and Cell Biology, Universidad Central del Caribe, Bayamón PR.
Rivera LinnetteLaboratory of Anatomy and Cell Biology, Universidad Central del Caribe, Bayamón PR.
Ledesma NahomyUniversity of Puerto Rico-Rio Piedras, Department of Biology.
Manne B KanthMolecular Medicine Program and Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Madera BismarckUniversity of Puerto Rico-Rio Piedras, Department of Biology.
Matthew T RondinaMolecular Medicine Program and Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Washington A ValanceUniversity of Puerto Rico-Rio Piedras, Department of Biology.
University of Puerto Rico at Río Piedras · PR

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
The Role of Sensory Input to Mammalian Locomotion After the Loss of supraspinal.P20GM103642 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LASALDE-DOMINICCI, JOSE ANTONIO · 2013 to 2023
$20.6M
Translational Research Skills Development CoreU54HL112311 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S, ZIMMERMAN, GUY A. · 2012 to 2016
$12.9M
The Effects of ART on Platelets and HIV-Associated ThrombosisR01HL126547 · NHLBI · UNIVERSITY OF UTAH · PI PLANELLES, VICENTE, RONDINA, MATTHEW THOMAS · 2014 to 2017
$3.0M
Translation Studies of the Planet Specific Receptor Trem Like Transcript (TLT)R01HL090933 · NHLBI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI WASHINGTON, A. VALANCE · 2011 to 2022
$2.9M
The Evaluation of TLT-1 as treatment for ALI/ARDSF31HL136183 · NHLBI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI MORALES-ORTIZ, JESSICA · 2017 to 2018
$49k
NHLBI NIH HHS F31 HL136183NHLBI NIH HHS R01 HL090933NHLBI NIH HHS R01 HL126547NHLBI NIH HHS U54 HL112311NIGMS NIH HHS P20 GM103475NIGMS NIH HHS P20 GM103642
6 · The paper itself

Abstract

Platelets regulate inflammation as well as hemostasis. Inflammatory insults often induce hemostatic function through mechanisms that are not always understood. The triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is an abundantly expressed platelet receptor and its deletion leads to hemorrhage and edema after lipopolysaccharide and TNF-α treatment. To define a role for TLT-1 in immune derived bleeding we used a CXCL-2 mediated local inflammatory reaction in the vessels of the cremaster muscle of

Indexed as

alpha granulesoutside-in signalingplateletsTREM-Like transcript (TLT)-1αIIbβ3

Identifiers

PMID30931337
PMCPMC6437137
OpenAlexW2888938863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.