ReviewFrontiers in medicine2019
Misconceptions and Barriers to the Use of Hypertonic Saline to Treat Hyponatremic Encephalopathy.
Review in Frontiers in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Fluid management in children with volume depletion.Pediatric nephrology (Berlin, Germany) · 2024Review
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Incidence and Severity of Community- and Hospital-Acquired Hyponatremia in Pediatrics.Journal of clinical medicine · 2022Article
- Administration of 3% Sodium Chloride and Local Infusion Reactions.Children (Basel, Switzerland) · 2022Article
- Clinical application of 2.16% hypertonic saline solution to correct the blood sodium concentration in diarrheic calves with hyponatremia.The Journal of veterinary medical science · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremic encephalopathy is a potentially life-threatening condition with a high associated morbidity and mortality. It can be difficult to diagnose as the presenting symptoms can be non-specific and do not always correlate with the degree of hyponatremia. It can rapidly progress leading to death from transtentorial herniation. Hypertonic saline is the recommended treatment for hyponatremic encephalopathy, whether acute or chronic, yet it is infrequently used. We believe that the main barriers to its use is the perception that hypertonic saline is associated with a significant risk for cerebral demyelination, that it can't be administered through a peripheral IV and that it requires monitoring in the ICU. Two illustrative cases are presented followed by a discussion of how intermittent bolus's of 100-150 ml of 3% NaCl in rapid succession to acutely increase the plasma sodium by 4-6 mEq/L is a safe and effective way to treat hyponatremic encephalopathy, that can be administered through a peripheral IV in a non-ICU setting.
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Registered trials
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