Evidence map›Paper›PMID 30931254›Full record

ArticleFrontiers in oncology2019

Expression of PD-L1 and PD-1 in Chemoradiotherapy-Naïve Esophageal and Gastric Adenocarcinoma: Relationship With Mismatch Repair Status and Survival.

Maria C Svensson, David Borg, Cheng Zhang, Charlotta Hedner, Björn Nodin, Mathias Uhlén, Adil Mardinoglu, Karin Leandersson, Karin Jirström

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04404491 (The Third Phase of Immunotherapy and Concurrent Chemoradiotherapy in Patients With Esophageal Cancer Recurrence Was Compared With the Clinical Comparison), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04404491 phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

The Third Phase of Immunotherapy and Concurrent Chemoradiotherapy in Patients With Esophageal Cancer Recurrence Was Compared With the Clinical Comparison

TypeinterventionalSponsorThe First Affiliated Hospital of Henan University of Science and TechnologyRan2020 to 2023Enrolled240ConditionsEsophageal Malignant Neoplasm, Local RecurrenceArmsProcedural death 1, Capecitabine, Radiotherapy, Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Prognostic role and clinical significance of tumor-infiltrating lymphocyte (TIL) and programmed death ligand 1 (PD-L1) expression in gastric cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Pooled it
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  7. Heterogeneity of predictive biomarker expression in gastric and esophago-gastric junction carcinoma with peritoneal dissemination.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maria C SvenssonDepartment of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden.
David BorgDepartment of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden.
Cheng ZhangScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.
Charlotta HednerDepartment of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden.
Björn NodinDepartment of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden.
Mathias UhlénScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.
Adil MardinogluScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.
Karin LeanderssonCancer Immunology, Department of Translational Medicine, Lund University, Malmö, Sweden.
Karin JirströmDepartment of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden.
Lund University · SEScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

esophageal cancergastric cancerMMR statusMSI statusPD-1PD-L1the cancer genome atlas

Identifiers

PMID30931254
PMCPMC6425870
OpenAlexW2922448828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.