Evidence map›Paper›PMID 30931169›Full record

ArticleJournal of health & pollution2019

Effect of Polycyclic Aromatic Hydrocarbons Exposure on Sperm DNA in Idiopathic Male Infertility.

Aziza A Saad, Tarek Hussein, Amany El-Sikaily, Mohamed A Abdel-Mohsen, El-Hassan Mokhamer, Amany I Youssef, Jihan Mohammed

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of health & pollution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Aziza A SaadApplied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Tarek HusseinDermatology, Venereology and Andrology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Amany El-SikailyMarine Pollution Department, Marine Environment Division, National Institute of Oceanography and Fisheries, Alexandria, Egypt.
Mohamed A Abdel-MohsenApplied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
El-Hassan MokhamerMolecular Biology lecturer, Zoology Department, Damnhour University, Damanhur, Egypt.
Amany I YoussefApplied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Jihan MohammedApplied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Alexandria University · EGDamanhour University · EGNational Institute of Oceanography and Fisheries · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiological mechanisms contribute to the relationship between polycyclic aromatic hydrocarbon (PAH) exposure and infertility in males by altering semen quality.

objectivesThe aim of the present study was to evaluate the impact of PAHs on male infertility using the sperm chromatin dispersion test (Halo sperm assay).

methodsSixty-six (66) infertile males under 45 years of age were examined for the determination of urinary metabolite and oxidative stress by measuring lipid peroxidation and antioxidant activity of glutathione and glutathione-s-transferase, as well as hormonal activity of follicle stimulating hormone (FSH), testosterone and prolactin and semen quality.

resultsThere was an increased level of urinary metabolite of 1-hydroxy pyrene, 1-hydroxy naphthalene and 2-hydroxy naphthalene in the urine of the infertile group. In addition, elevated concentrations of malondialdehyde coincided with a decreased level of antioxidants, leading to oxidative stress in the infertile group. Semen samples showed 30% sperm deoxyribonucleic acid (DNA) fragmentation.

conclusionsThe data provide strong evidence of a statistical threshold for semen samples containing 30% sperm DNA fragmentation resulting in a reduced level of pregnancy success. PARTICIPANT CONSENT: Obtained. ETHICS APPROVAL: Study approval was given by the ethics committee of Alexandria University (United States Department of Health and Human Services, institutional review board registration (IRB), IORG0008812 Medical Research Institute, expires 4/8/2019, OMB No: 0990-0279). COMPETING INTERESTS: The authors declare no competing financial interests.

Indexed as

PAHsemensperm DNA fragmentationurinary metabolite

Identifiers

PMID30931169
PMCPMC6421954
OpenAlexW2602489646

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.