Evidence map›Paper›PMID 30931091›Full record

ArticleMedChemComm2019

Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis

Alessandro Ruffoni, Nicola Ferri, Andrea Pinto, Sara Pellegrino, Alessandro Contini, Francesca Clerici

Abstract read
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alessandro RuffoniSchool of Chemistry , University of Manchester , Manchester , M13 9PL , UK . Email: alessandro.ruffoni@manchester.ac.uk.ORCID 0000-0001-8617-2548
Nicola FerriDepartment of Pharmaceutical and Pharmacological Sciences , Via Marzolo 5 , 35131 Padua , Italy.ORCID 0000-0001-8898-7441
Andrea PintoDepartment of Food, Environmental and Nutritional Sciences (DeFENS) , Via Mangiagalli 25 , 20133 Milano , Italy.ORCID 0000-0002-2501-3348
Sara PellegrinoDepartment of Pharmaceutical Sciences , General and Organic Chemistry Section "Alessandro Marchesini" , Via Venezian 21 , 20133 Milano , Italy . Email: francesca.clerici@unimi.it.ORCID 0000-0002-2325-3583
Alessandro ContiniDepartment of Pharmaceutical Sciences , General and Organic Chemistry Section "Alessandro Marchesini" , Via Venezian 21 , 20133 Milano , Italy . Email: francesca.clerici@unimi.it.ORCID 0000-0002-4394-8956
Francesca ClericiDepartment of Pharmaceutical Sciences , General and Organic Chemistry Section "Alessandro Marchesini" , Via Venezian 21 , 20133 Milano , Italy . Email: francesca.clerici@unimi.it.ORCID 0000-0003-3483-5914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A phospine free hydroarylation reaction applied to norbornene derivatives is described for the first time and was exploited for the regioselective gram scale synthesis of

Identifiers

PMID30931091
PMCPMC6396393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.