Evidence map›Paper›PMID 30930867›Full record

ArticleFrontiers in microbiology2019

Alveolar Macrophages Treated With

Ji Eun Hong, Yoon-Chul Kye, Sung-Moo Park, In Su Cheon, Hyuk Chu, Byung-Chul Park, Yeong-Min Park, Jun Chang, Jae-Ho Cho, Man Ki Song and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05164692 (Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Respiratory Syncytial Virus), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05164692 nacompletednot on this mapstarted 2020, after this paper: background citation

Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Respiratory Syncytial Virus

TypeinterventionalSponsorNational Children's Hospital, VietnamRan2020 to 2021Enrolled100ConditionsAcute Respiratory Tract InfectionsArmsLiveSpo Navax, 0.9% NaCl physiological saline
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Disruption of Spore Coat Integrity inCurrent issues in molecular biology · 2025
    Article
  5. Review
  6. Co-injection with inactivatedFrontiers in microbiology · 2025
    Article
  7. Nasal delivery of killedFrontiers in immunology · 2025
    Article
  8. Article
  9. Article
  10. Effects ofFoods (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Review
  13. The Role of Innate Immunity in Pulmonary Infections.BioMed research international · 2021
    Review
  14. Viruses · 2020
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Ji Eun HongDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.
Yoon-Chul KyeDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.
Sung-Moo ParkDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.
In Su CheonDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.
Hyuk ChuDivision of Zoonoses, Center for Immunology and Pathology, Korea Center for Disease Control and Prevention, National Institute of Health, Cheongju, South Korea.
Byung-Chul ParkInstitute of Green Bio Science and Technology, Seoul National University, Seoul, South Korea.
Yeong-Min ParkDepartment of Immunology, School of Medicine, Konkuk University, Chungju, South Korea.
Jun ChangGraduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea.
Jae-Ho ChoAcademy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea.
Man Ki SongLaboratory Science Division, Department of Molecular Vaccinology, International Vaccine Institute, Seoul, South Korea.
Seung Hyun HanDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Cheol-Heui YunDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.
Seoul National University · KRInternational Vaccine Institute · KREwha Womans University · KRInstitute for Basic Science · KRKonkuk University · KRKorea Center for Disease Control and Prevention · KRSeoul National University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a major pathogen that infects lower respiratory tract and causes a common respiratory disease. Despite serious pathological consequences with this virus, effective treatments for controlling RSV infection remain unsolved, along with poor innate immune responses induced at the initial stage of RSV infection. Such a poor innate defense mechanism against RSV leads us to study the role of alveolar macrophage (AM) that is one of the primary innate immune cell types in the respiratory tract and may contribute to protective responses against RSV infection. As an effective strategy for enhancing anti-viral function of AM, this study suggests the intranasal administration of

Indexed as

alveolar macrophage activationBacillus subtilisMyD88respiratory syncytial virusspore

Identifiers

PMID30930867
PMCPMC6423497
OpenAlexW2921242268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.