Evidence map›Paper›PMID 30930866›Full record

ReviewFrontiers in microbiology2019

Nutrient and Stress Sensing in Pathogenic Yeasts.

Julian C Rutherford, Yong-Sun Bahn, Bert van den Berg, Joseph Heitman, Chaoyang Xue

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Comprehensive Insights into Sugar Transporters ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Cryptococcal nutrient acquisition and pathogenesis: dining on the host.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  8. Deciphering cargo contents in extracellular vesicles ofComputational and structural biotechnology journal · 2025
    Article
  9. Article
  10. Measuring Stress Phenotypes in Cryptococcus neoformans.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  11. Article
  12. Connecting Cryptococcal Meningitis and Gut Microbiome.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Molecular association ofFrontiers in cellular and infection microbiology · 2023
    Review
  15. Article
  16. mBio · 2022
    Article
  17. Review
  18. Review
  19. Fungicidal Activity of Recombinant Javanicin againstMolecules (Basel, Switzerland) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Julian C RutherfordInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Yong-Sun BahnDepartment of Biotechnology, Yonsei University, Seoul, South Korea.
Bert van den BergInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States.
Chaoyang XuePublic Health Research Institute, Rutgers University, Newark, NJ, United States.
Newcastle University · GBDuke Medical Center · USRutgers, The State University of New Jersey · USYonsei University · KR

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
The role of inositol in Cryptococcus biology and pathogenesisR01AI123315 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Chaoyang Xue · 2017 to 2026
$5.0M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI123315NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

More than 1.5 million fungal species are estimated to live in vastly different environmental niches. Despite each unique host environment, fungal cells sense certain fundamentally conserved elements, such as nutrients, pheromones and stress, for adaptation to their niches. Sensing these extracellular signals is critical for pathogens to adapt to the hostile host environment and cause disease. Hence, dissecting the complex extracellular signal-sensing mechanisms that aid in this is pivotal and may facilitate the development of new therapeutic approaches to control fungal infections. In this review, we summarize the current knowledge on how two important pathogenic yeasts,

Indexed as

fungal pathogenG protein-coupled receptorMep2nutrient sensingstress responseTortransceptoryeast

Identifiers

PMID30930866
PMCPMC6423903
OpenAlexW2921118877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.