ArticleFrontiers in endocrinology2019
Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat.
Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Ginsenoside Rb2 modulates the skin barrier by targeting Src to regulate PI3K/Akt signaling in HaCaT cells.Journal of ginseng research · 2026Article
- A Combination of Plant-Derived Extracts Modulates Nutrient-Responsive Metabolic Signalling in an In Vitro Gut-Liver-Adipose Model.Nutrients · 2026Article
- Mechanistic insights into the regulation of glucose‒lipid metabolism by the bioactive constituents of ginseng.Journal of ginseng research · 2026Review
- Clinical randomized controlled trial and network pharmacological analysis of blood glucose regulation by Korean red ginseng in patients with type 2 diabetes and impaired glucose regulation.Journal of ginseng research · 2026Article
- An In Vitro Gut-Liver-Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic-Polycosanol Combination.Foods (Basel, Switzerland) · 2025Article
- Unveiling the Potential of Natural Compounds: A Comprehensive Review on Adipose Thermogenesis Modulation.International journal of molecular sciences · 2024Review
- Research advances in the therapy of metabolic syndrome.Frontiers in pharmacology · 2024Review
- By-Product of the Red Ginseng Manufacturing Process as Potential Material for Use as Cosmetics: Chemical Profiling and In Vitro Antioxidant and Whitening Activities.Molecules (Basel, Switzerland) · 2022Article
- Metformin Inhibits Lipid Droplets Fusion and Growth via Reduction in Cidec and Its Regulatory Factors in Rat Adipose-Derived Stem Cells.International journal of molecular sciences · 2022Article
- Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects.Journal of ginseng research · 2022Review
- Immunomodulatory Effect of Ginsenoside Rb2 Against Cyclophosphamide-Induced Immunosuppression in Mice.Frontiers in pharmacology · 2022Article
- An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications.Frontiers in endocrinology · 2022Review
- Jinlida Granules Reduce Obesity in db/db Mice by Activating Beige Adipocytes.BioMed research international · 2022Article
- The effects of ginseng on the metabolic syndrome: An updated review.Food science & nutrition · 2021Review
- Natural Extracts That Stimulate Adipocyte Browning and Their Underlying Mechanisms.Antioxidants (Basel, Switzerland) · 2021Review
- Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by Ginsenosides.Biomedicines · 2021Review
- Ginsenoside Rb1 Facilitates Browning by Repressing Wnt/β-Catenin Signaling in 3T3-L1 Adipocytes.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Ginsenoside Rb2 Alleviated Atherosclerosis by Inhibiting M1 Macrophages Polarization Induced by MicroRNA-216a.Frontiers in pharmacology · 2021Article
- Recruitment of Thermogenic Fat: Trigger of Fat Burning.Frontiers in endocrinology · 2021Review
- Antiviral Effect of Ginsenoside Rb2 and Rb3 Against Bovine Viral Diarrhea Virus and Classical Swine Fever VirusFrontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ginsenoside Rb2 (Rb2), the most abundant saponin contained in Panax ginseng, has been used to treat variety of metabolic diseases. However, its effects in obesity and potential mechanisms are not well-understood. In the present study, we investigated metabolic performance with a Rb2 supplement in diet-induced obese (DIO) mice, focusing on the effects and mechanisms of Rb2 on brown and beige fat functions. Our results demonstrated that Rb2 effectively reduced body weight, improved insulin sensitivity, as well as induced energy expenditure in DIO mice. Histological and gene analysis revealed that Rb2 induced activation of brown fat and browning of white fat by reducing lipid droplets, stimulating uncoupling protein 1 (UCP1) staining, and increasing expression of thermogenic and mitochondrial genes, which could be recapitulated in 3T3-L1, C3H10T1/2, and primary adipocytes. In addition, Rb2 induced phosphorylation of AMP-activated protein kinase (AMPK) both
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