ArticleFrontiers in neurology2019
The Conjoint Analysis of Microstructural and Morphological Changes of Gray Matter During Aging.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury?Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Exercise Training-Related Changes in Cortical Gray Matter Diffusivity and Cognitive Function in Mild Cognitive Impairment and Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
- Associations between Age-Related Changes in the Core Vestibular Projection Pathway and Balance Ability: A Diffusion Tensor Imaging Study.Behavioural neurology · 2020Article
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Authors and funding
6 authors.
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Abstract
Macromorphological and microstructural changes of gray matter (GM) happen during brain normal aging. However, the mechanism of macro-microstructure association is still unclear, which is of guidance for understanding many neurodegenerative diseases. In this study, adopting structural magnetic resonance imaging (sMRI) and diffusion kurtosis imaging (DKI), GM aging pattern was characterized and its macro-microstructure associations were revealed. For 60 subjects among the ages of 47-79, the DKI and T1-weighted images were investigated with voxel-based analysis. The results showed age-related overlapped patterns between morphological and microstructural alterations during normal aging. It was worth noting that morphological changes and mean diffusivity (MD) indexes abnormalities mainly overlapped in the following regions, superior frontal gyrus, inferior frontal gyrus, cingulum gyrus, superior temporal gyrus, insula, and thalamus. Besides, overlapped with GM atrophies, mean kurtosis (MK) abnormalities were observed in superior frontal gyrus, inferior frontal gyrus, transverse temporal gyrus, insula, and thalamus. What important was that intrinsic aging independent associations between macrostructure and microstructure were found especially in media superior frontal gyrus, which revealed the potential mechanisms in the process of aging. The physiological mechanism may be associated with the elimination of neurons and synapses and the shrinkage of large neurons. Understanding the associations of GM volume changes and microstructural changes can account for the underlying mechanisms of aging and age-related neurodegenerative diseases.
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