ReviewFrontiers in physiology2019
Understanding Molecular Mechanisms of the Brain Through Transcriptomics.
Review in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Endoplasmic reticulum stress of astrocytes in paraventricular nucleus of hypothalamus promotes ventricular electrical instability after acute myocardial infarction in rats.Frontiers in cardiovascular medicine · 2025Article
- BrainCellR: A precise cell type nomenclature pipeline for comparative analysis across brain single-cell datasets.Computational and structural biotechnology journal · 2024Article
- Gene co-expression network and differential expression analyses reveal key genes for weaning weight in Simmental-Holstein crossbred cattle.Animal biotechnology · 2024Article
- High-resolution diffusion magnetic resonance imaging and spatial-transcriptomic in developing mouse brain.NeuroImage · 2024Article
- Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin-embedded brain tissue.Brain communications · 2024Article
- Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain.Genetics · 2023Article
- scBrainMap: a landscape for cell types and associated genetic markers in the brain.Database : the journal of biological databases and curation · 2023Article
- Sex Differences in Depression and Anxiety.Current topics in behavioral neurosciences · 2023Article
- Functional orderly topography of brain networks associated with gene expression heterogeneity.Communications biology · 2022Article
- Rapid Body-Wide Transcriptomic Turnover During Rhesus Macaque Perinatal Development.Frontiers in physiology · 2021Article
- Time-Varying Gene Network Analysis of Human Prefrontal Cortex Development.Frontiers in genetics · 2020Article
- C3orf70 Is Involved in Neural and Neurobehavioral Development.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Studies on copper (II) interaction with the (CCG)Journal of Alzheimer's disease reportsArticle
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is the most complicated organ in the human body with more than ten thousand genes expressed in each region. The molecular activity of the brain is divergent in various brain regions, both spatially and temporally. The function of each brain region lies in the fact that each region has different gene expression profiles, the possibility of differential RNA splicing, as well as various post-transcriptional and translational modification processes. Understanding the overall activity of the brain at the molecular level is essential for a comprehensive understanding of how the brain works. Fortunately, the development of next generation sequencing technology has made it possible to measure the molecular activity of a specific tissue as a daily routine approach of research. Therefore, at the molecular level, the application of sequencing technology to investigate the molecular organization of the brain has become a novel field, and significant progress has been made recently in this field. In this paper, we reviewed the major computational methods used in the analysis of brain transcriptome, including the application of these methods to the research of human and non-human mammal brains. Finally, we discussed the utilization of transcriptome methods in neurological diseases.
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