ArticleFrontiers in cellular neuroscience2019
The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior.
Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- The multifaceted role of ASICs channels into the nervous system and their potential use as a therapeutic target for neuro-disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- A role for proprioceptors in sngception.Science advances · 2025Article
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- The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders.Neuropsychiatric disease and treatment · 2023Review
- ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.American journal of human genetics · 2022Article
- Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice.Molecular brain · 2022Article
- Differentially Expressed Genes inBiomolecules & therapeutics · 2022Article
- Acid-Sensing Ion Channels in Glial Cells.Membranes · 2022Review
- The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia.Frontiers in pharmacology · 2022Article
- Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Acid-Sensing Ion Channels and Mechanosensation.International journal of molecular sciences · 2021Review
- Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels.Biomolecules · 2020Article
- Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain.Frontiers in neuroscience · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stereotypic and/or repetitive behavior is one of the major symptoms of autism spectrum disorder (ASD). Increase of self-grooming behavior is a behavioral phenotype commonly observed in the mouse models for ASD. Previously, we have shown that knockout of acid-sensing ion channel 3 (ASIC3) led to the increased self-grooming behavior in resident-intruder test. Given the facts that ASIC3 is mainly expressed in the peripheral dorsal root ganglion (DRG) and conditional knockout of ASIC3 in the proprioceptors induced proprioception deficits. We speculate a hypothesis that stereotypic phenotype related to ASD, pararalled with striatal dysfunction, might be caused by proprioception defect in the peripheral sensory neuron origin. Herein, we investigate in depth whether and how ASIC3 is involved in the regulation of self-grooming behavior. First, we observed that
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