Evidence map›Paper›PMID 30930725›Full record

ArticleFrontiers in neuroscience2019

3'-Daidzein Sulfonate Sodium Protects Against Chronic Cerebral Hypoperfusion-Mediated Cognitive Impairment and Hippocampal Damage via Activity-Regulated Cytoskeleton-Associated Protein Upregulation.

Qi Zeng, Zhihua Huang, Jiandong Zhang, Ruizhen Liu, Xiao Li, Jing Zeng, Hai Xiao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qi ZengDepartment of Ultrasound, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Zhihua HuangSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Jiandong ZhangSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Ruizhen LiuSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Xiao LiSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Jing ZengSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Hai XiaoDepartment of Pathology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Gannan Medical University · CNFirst Affiliated Hospital of Gannan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The learning and memory impairment caused by chronic cerebral hypoperfusion (CCH) is permanent and seriously affects the daily life of patients and their families. The compound 3'-daidzein sulfonate sodium (DSS) protects against CCH-mediated memory impairment and hippocampal damage in a rat model. In the present study, we further investigated the underlying mechanisms of this effect in the rat two-vessel occlusion (2VO) and the oxygen and glucose deprivation (OGD) primary hippocampal neuron models. The hippocampal expression of the activity-regulated cytoskeleton associated protein (Arc) following DSS administration was detected

Indexed as

3′-daidzein sulfonate sodiumactivity-regulated cytoskeleton-associated proteinchronic cerebral hypoperfusioneffective druglearning and memory deficits

Identifiers

PMID30930725
PMCPMC6424008
OpenAlexW2914868351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.