Evidence map›Paper›PMID 30930693›Full record

ArticleCancer cell international2019

Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.

Xiangyi Zhe, Huizhen Xin, Zhenzhen Pan, Fuyuan Jin, Weinan Zheng, Hongtao Li, Dongmei Li, Dongdong Cao, Ying Li, Chunhe Zhang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancer cell international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  20. Analysis of Human Papillomavirus (HPV) 16 Variants Associated with Cervical Infection in Italian Women.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Xiangyi Zhe *1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Huizhen Xin *1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Zhenzhen PanXinjiang Production and Construction Corps of the Fourth Division Hospital, Yining, 835000 Xinjiang China.
Fuyuan Jin1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Weinan Zheng1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Hongtao Li1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Dongmei Li1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Dongdong Cao1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Ying Li1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Chunhe Zhang1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Shaowei Fu1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Renfu Shao3School of Science and Engineering, Genecology Research Centre, The Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556 Australia.
Zemin Pan1Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002 Xinjiang China.
Shihezi University · CNUniversity of the Sunshine Coast · AUXinjiang Production and Construction Corps · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundXinjiang is one of the areas with the highest incidence of cervical cancer in China. Genetic variation in Human papillomavirus type 16 (HPV16) may increase the ability of the virus to mediate carcinogenesis and immune escape, which are risk factors for the progression of cervical cancer. We investigated polymorphism in HPV16 and the distribution of its sub-lineages in the region by analyzing the

methodsA total of 138 cases of cervical lesions and squamous cell carcinoma with infection of HPV16 virus were collected. The

resultsFourteen missense mutations were found in the

conclusionHPV16 in Xinjiang is mainly of the European variant, followed by the Asian variant type; no Africa 1, 2 or Asia-America variant types were found.

Indexed as

Cervical cancerGenetic variationsHuman papillomavirusPhylogenetic treePolymorphism analysis

Identifiers

PMID30930693
PMCPMC6425590
OpenAlexW2936078327

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.