Evidence map›Paper›PMID 30930529›Full record

ArticleJournal of carbohydrate chemistry2017

A facile synthesis of a complex type N-glycan thiazoline as an effective inhibitor against the antibody-deactivating endo-β-N-acetylglucosaminidases.

Chao Li, Shilei Zhu, Xin Tong, Chong Ou, Lai-Xi Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of carbohydrate chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chao LiDepartment of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, Maryland 20742, USA.
Shilei ZhuDepartment of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, Maryland 20742, USA.
Xin TongDepartment of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, Maryland 20742, USA.
Chong OuDepartment of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, Maryland 20742, USA.
Lai-Xi WangDepartment of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, Maryland 20742, USA.

Funding

Covergent Chemoenzymatic Synthesis of Glycopeptides and GlycoproteinsR01GM080374 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WANG, LAI-XI · 2007 to 2021
$3.9M
Synthesis and Function of Antibody Fc Domain GlycoformsR01GM096973 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WANG, LAI-XI · 2011 to 2020
$2.4M
NIGMS NIH HHS R01 GM080374NIGMS NIH HHS R01 GM096973
6 · The paper itself

Abstract

Endo-β-N-acetylglucosaminidases are a class of endoglycosidases that deglycosylate N-glycans from glycoproteins. We describe here a facile synthesis of a complex type N-glycan thiazoline as a new mechanism-based inhibitor for this class of enzymes. The synthesis started with the readily available sialoglycopeptide (SGP) and its conversion into the glycan thiazoline through several enzymatic and chemical reactions. The synthetic glycan thiazoline showed potent inhibitory activity against several endoglycosidases including the two antibody-deactivating enzymes, Endo-S and Endo-S2, from human pathogen

Indexed as

AntibodyComplex type N-glycanendo-β-N-AcetylglucosaminidaseEnzymatic deglycosylationEnzyme inhibitorOligosaccharide thiazoline

Identifiers

PMID30930529
PMCPMC6436815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.