Evidence map›Paper›PMID 30930293›Full record

ReviewBone2019

Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength.

Brittany C Collins, Eija K Laakkonen, Dawn A Lowe

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07302750 (The Effectiveness of Artificial Intelligence-Assisted Relaxation and Breathing Training on Pain Intensity and Quality of Life in Postmenopausal Women), which is not on this map. Cited by 127 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 10 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07302750 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effectiveness of Artificial Intelligence-Assisted Relaxation and Breathing Training on Pain Intensity and Quality of Life in Postmenopausal Women

TypeinterventionalSponsorBaskent UniversityRan2026 to 2027Enrolled48ConditionsPostmenopausal Period, Postmenopausal WomenArmsPhysiotherapist-Guided Relaxation and Breathing Training, Artificial Intelligence-Assisted Relaxation and Breathing Training, Control Group - No Structured Training Program
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 10 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  17. Article
  18. Sex hormones and menopause hormone therapy predict muscle strength across the lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Brittany C CollinsDepartment of Human Genetics, Medical School, University of Utah, United States of America.
Eija K LaakkonenGerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.
Dawn A LoweDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, United States of America. Electronic address: lowex017@umn.edu.
University of Jyväskylä · FIUniversity of Minnesota Medical Center · USUniversity of Utah · US

Funding

Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8M
NIA NIH HHS R01 AG031743NIDDK NIH HHS T32 DK091317
6 · The paper itself

Abstract

Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen. Evidence is accumulating that estrogen deficiency induces apoptosis in skeletal muscle contributing to loss of mass and thus strength. Estrogen sensitive processes that affect quality, i.e., force generating capacity of muscle, include myosin phosphorylation and satellite cell function. Further detailing these mechanisms and identifying additional mechanisms that underlie estrogenic effects on skeletal muscle is important foundation for the design of therapeutic strategies to minimize skeletal muscle pathologies, such as sarcopenia and dynapenia.

Indexed as

AgingApoptosisEstrogensFemaleHumansMuscle, SkeletalMuscle StrengthProteasome Endopeptidase ComplexUbiquitinationEstrogensProteasome Endopeptidase ComplexAgingEstrogenSkeletal muscleStrength

Identifiers

PMID30930293
PMCPMC6491229
OpenAlexW2930185787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.