Evidence map›Paper›PMID 30930064›Full record

ArticleStructure (London, England : 1993)2019

Ion and pH Sensitivity of a TMBIM Ca

Gongrui Guo, Min Xu, Yanqi Chang, Tomas Luyten, Bruno Seitaj, Wu Liu, Ping Zhu, Geert Bultynck, Lei Shi, Matthias Quick and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Intracellular CaBiologia futura · 2025
    Review
  4. Article
  5. Article
  6. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  7. Review
  8. TMBIM5 is the CaEMBO reports · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Structure and regulation of the BsYetJ calcium channel in lipid nanodiscs.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
  15. Review
  16. Review
  17. Bcl-2-Protein Family as Modulators of IPCold Spring Harbor perspectives in biology · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Gongrui GuoBiology Department, Brookhaven National Laboratory, Upton, NY 11973, USA; NSLS-II, Brookhaven National Laboratory, Upton, NY 11973, USA.
Min XuComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, Baltimore, MA 21224, USA.
Yanqi ChangNew York Consortium on Membrane Protein Structure, New York Structural Biology Center, New York, NY 10027, USA.
Tomas LuytenLaboratory Molecular and Cellular Signaling, Department Cellular and Molecular Medicine, Campus Gasthuisberg O/N-I Bus 802, Herestraat 49 3000 Leuven, Belgium.
Bruno SeitajLaboratory Molecular and Cellular Signaling, Department Cellular and Molecular Medicine, Campus Gasthuisberg O/N-I Bus 802, Herestraat 49 3000 Leuven, Belgium.
Wu LiuBiology Department, Brookhaven National Laboratory, Upton, NY 11973, USA; NSLS-II, Brookhaven National Laboratory, Upton, NY 11973, USA.
Ping ZhuBiology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Geert BultynckLaboratory Molecular and Cellular Signaling, Department Cellular and Molecular Medicine, Campus Gasthuisberg O/N-I Bus 802, Herestraat 49 3000 Leuven, Belgium.
Lei ShiComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, Baltimore, MA 21224, USA. Electronic address: lei.shi2@nih.gov.
Matthias QuickDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address: mq2102@cumc.columbia.edu.
Qun LiuBiology Department, Brookhaven National Laboratory, Upton, NY 11973, USA; NSLS-II, Brookhaven National Laboratory, Upton, NY 11973, USA. Electronic address: qunliu@bnl.gov.
Brookhaven National Laboratory · USNational Institutes of Health · USNew York Psychoanalytic Society and Institute · USNew York Structural Biology Center · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptorZIADA000606 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHI, LEI · 2015 to 2025
$20.5M
Training (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1M
Molecular mechanism of nucleobase/vitamin C transportersR01GM119396 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUICK, MATTHIAS · 2016 to 2020
$1.9M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
EPA EP-C-17-023EPA EP-D-17-023Intramural NIH HHS ZIA DA000606NCRR NIH HHS S10 RR029205NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM119396
6 · The paper itself

Abstract

The anti-apoptotic transmembrane Bax inhibitor motif (TMBIM) containing protein family regulates Ca

Indexed as

ProtonsAmino Acid MotifsApoptosisBacillus subtilisBacterial ProteinsCalciumCrystallography, X-RayHeLa CellsHumansHydrogen-Ion ConcentrationMembrane ProteinsMolecular Dynamics SimulationProtein BindingBacterial ProteinsCalciumMembrane ProteinsProtonsRECS1 protein, mouseCa(2+) channel structureCa(2+) effluxion sensitivitymolecular dynamics simulationpH sensorproton sensitivity

Identifiers

PMID30930064
PMCPMC6560632
OpenAlexW2932263800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.