Trial reportSchizophrenia research2019
Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial.
Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy of User Self-Led and Human-Supported Digital Health Interventions for People With Schizophrenia: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2025Pooled it
- Efficacy of technology-based interventions in psychosis: a systematic review and network meta-analysis.Psychological medicine · 2023Pooled it
- Acceptability of cognitive remediation for schizophrenia: a systematic review and meta-analysis of randomized controlled trials.Psychological medicine · 2023Pooled it
- Factors Impacting Access and Engagement of Cognitive Remediation Therapy for People with Schizophrenia: A Systematic Review.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Pooled it
- Augmenting Computerized Cognitive Training With Vortioxetine for Age-Related Cognitive Decline: A Randomized Controlled Trial.The American journal of psychiatry · 2020Trial
- Exploring the General Acceptability and User Experience of a Digital Therapeutic for Cognitive Training in a Singaporean Older Adult Population: Qualitative Study.JMIR formative research · 2025Article
- Multidisciplinary cognitive performance optimization for mission-critical decision makers: delivering "the whole pizza".Frontiers in neurology · 2025Article
- Article
- Efficacy of cognitive training on cognition, symptoms and functioning: Impact of motivation and attendance.Schizophrenia research. Cognition · 2024Article
- Improving Neurological Health in Aging Via Neuroplasticity-Based Computerized Exercise: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- "Food for Thought": Improving Cognition in People With Schizophrenia.Psychiatry investigation · 2024Article
- Feasibility of six-month outpatient cognitive remediation in schizophrenia: Experience from the randomized controlled integrated social cognition and social skills therapy study.Schizophrenia research. Cognition · 2023Article
- The MATRICS Consensus Cognitive Battery: An Update.Current topics in behavioral neurosciences · 2023Article
- Artificial Cognitive Systems Applied in Executive Function Stimulation and Rehabilitation Programs: A Systematic Review.Arabian journal for science and engineering · 2023Article
- Appropriate controls for digital therapeutic clinical trials: A narrative review of control conditions in clinical trials of digital therapeutics (DTx) deploying psychosocial, cognitive, or behavioral content.Frontiers in digital health · 2022Review
- Feasibility and preliminary effectiveness of mobile cognitive control training during basic combat training in the military.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2022Article
- Cognitive Remediation in Virtual Environments for Patients with Schizophrenia and Major Depressive Disorder: A Feasibility Study.International journal of environmental research and public health · 2021Article
- Feasibility and tolerability of a cognitive remediation clinical service in first episode coordinated specialty care.Early intervention in psychiatry · 2021Article
- Training engagement, baseline cognitive functioning, and cognitive gains with computerized cognitive training: A cross-diagnostic study.Schizophrenia research. Cognition · 2020Article
- Rethinking the effects of working memory training on executive functions in schizophrenia: A machine learning approach.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
objectiveCognitive impairment in schizophrenia is a core feature of the disorder. Computerized cognitive training has shown promise in pilot studies. A 26-week randomized blinded placebo-controlled trial was conducted to investigate the effect of a novel computerized cognitive training program on cognitive and functional capacity outcomes.
methodThe study followed MATRICS guidelines for the evaluation of interventions designed to improve cognitive function in schizophrenia. Participants (N = 150) were randomized to experimental (computerized cognitive training in a game-like format) or active control (computer games) groups. Training was conducted in-clinic, with an intended training schedule of 5 days per week, 1 h per day, for 26 weeks. Co-primary outcome measures were the MATRICS Consensus Cognitive Battery (MCCB) composite score and the UCSD Performance-Based Skills Assessment (UPSA-2) total score, secondary outcome measures included the Cognitive Assessment Interview (CAI) and the Short-Form-12 Mental Composite Score (SF-12 MCS). Target engagement was assessed with task-learning based assessment.
resultsAt baseline, the groups were well matched. No significant effect of the experimental treatment was seen on the primary or secondary outcome measures compared to the active control. Review of the task learning/target engagement data suggested inadequate target engagement.
conclusionsResults do not support a cognitive or functional capacity benefit from this implementation of a computerized cognitive training program in people with schizophrenia. In future trials, careful consideration is merited of the assessment of task learning/target engagement, the effects of making the cognitive training game-like on motivation, and the implicit effects of trial requirements on participant selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.