Evidence map›Paper›PMID 30930005›Full record

ArticleVaccine2019

Design of a mimotope-peptide based double epitope vaccine against disseminated candidiasis.

Hong Xin, Pati Glee, Abby Adams, Farhan Mohiuddin, Karen Eberle

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Vaccines against candidiasis: Status, challenges and emerging opportunity.Frontiers in cellular and infection microbiology · 2022
    Review
  6. Review
  7. Review
  8. Advances in Fungal Peptide Vaccines.Journal of fungi (Basel, Switzerland) · 2020
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hong XinDepartment of MIP & Pediatrics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA. Electronic address: hxin@lsuhsc.edu.
Pati GleeLigocyte Pharmaceuticals, Inc., Bozeman, MT 59718, USA.
Abby AdamsDepartment of MIP & Pediatrics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA.
Farhan MohiuddinLoyola University, 6363 St. Charles Avenue, New Orleans, LA, 70118, USA.
Karen EberleDepartment of MIP & Pediatrics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA.
Louisiana State University Health Sciences Center New Orleans · USLoyola University New Orleans · US

Funding

Design of a mimotope-peptide based double epitope vaccine against candidiasisR21AI113515 · NIAID · LSU HEALTH SCIENCES CENTER · PI XIN, HONG · 2015 to 2016
$391k
NIAID NIH HHS R21 AI113515
6 · The paper itself

Abstract

Hematogenously disseminated candidiasis in humans is the third leading cause of nosocomial bloodstream infections in the US. There is no FDA approved antifungal vaccine or prophylactic/therapeutic antibody for use in humans. We first reported novel synthetic peptide and glycopeptide vaccines against Candida albicans cell surface epitopes that protect mice against disseminated candidiasis. We showed that antibodies specific for the peptide Fba (derived from C. albicans cell surface protein fructose bisphosphate aldolase) or for C. albicans cell surface glycan epitope β-1, 2-mannotriose [β-(Man)

Indexed as

AnimalsAntibodies, FungalCandidiasisEpitopesFemaleFungal VaccinesMice, Inbred BALB CPolysaccharidesTrisaccharidesVaccinationVaccines, SubunitAntibodies, FungalEpitopesFungal VaccinesmannotriosePolysaccharidesTrisaccharidesVaccines, SubunitAntibody-mediated protectionCandida albicansCandidiasisMimotopePeptide vaccine

Identifiers

PMID30930005
PMCPMC6497404
OpenAlexW2933691382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.