Evidence map›Paper›PMID 30930001›Full record

ReviewTrends in microbiology2019

Influenza Neuraminidase: Underrated Role in Receptor Binding.

Feng Wen, Xiu-Feng Wan

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  13. Article
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  17. Article
  18. Sialic acid: an attractive biomarker with promising biomedical applications.Asian biomedicine : research, reviews and news · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Feng WenDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.
Xiu-Feng WanDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA. Electronic address: wan@cvm.msstate.edu.
Mississippi State University · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Zinc dependent conformational changes in AdcR and their impact on DNA bindingP20GM103646 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI THIBAUDEAU, GISELLE · 2013 to 2022
$21.1M
Use of Clinical Samples to Identify Influenza Virus Antigenic VariantsR01AI147640 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI WAN, XIUFENG HENRY · 2019 to 2024
$2.8M
Genome Based Influenza Vaccine Strain Selection using Machine LearningR01AI116744 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI WAN, XIUFENG HENRY · 2015 to 2019
$1.9M
Glycan receptors specific for canine influenza infectionR15AI107702 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI WAN, XIUFENG HENRY · 2013 to 2013
$425k
Prediction of influenza antigenic variants using a novel sparse multitask learninRC1AI086830 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI WAN, XIUFENG HENRY · 2010 to 2010
$413k
NIAID NIH HHS R01 AI116744NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Influenza virus neuraminidase cleaves sialic acid groups from cell glycoproteins, enabling release of the virus from host cells. Neuraminidase also contributes to virus binding to the sialic acid groups of cell glycoproteins, which could complement the receptor-binding function of hemagglutinin, enhancing enzymatic activities of neuraminidase, and facilitate virus infection.

Indexed as

AnimalsHost-Pathogen InteractionsHumansInfluenza A virusInfluenza, HumanN-Acetylneuraminic AcidNeuraminidaseOrthomyxoviridae InfectionsProtein BindingReceptors, VirusViral ProteinsVirus AttachmentN-Acetylneuraminic AcidNA protein, influenza A virusNeuraminidaseReceptors, VirusViral Proteinsinfluenza A virusinfluenza virusneuraminidasereceptorreceptor bindingsialic acids

Identifiers

PMID30930001
PMCPMC6527465
OpenAlexW2927178773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.