ArticleCell reports2019
A Ubiquitous Platform for Bacterial Nanotube Biogenesis.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge.bioRxiv : the preprint server for biology · 2026Article
- A family of endonucleases blocks nanotube-mediated plasmid exchange.Nature microbiology · 2026Article
- Review
- From genes to nanotubes: exploring the UV-resistome in the Andean extremophile Exiguobacterium sp. S17.Extremophiles : life under extreme conditions · 2025Article
- Gram Negative Biofilms: Structural and Functional Responses to Destruction by Antibiotic-Loaded Mixed Polymeric Micelles.Microorganisms · 2024Article
- Atomic Force Microsocopy: Key Unconventional Approach for Bacterial Nanotubes Characterization In Vivo.ACS omega · 2024Article
- Direct interaction between marine cyanobacteria mediated by nanotubes.Science advances · 2024Article
- Nanotube-mediated plasmid transfer as a natural alternative for the improvement of industrially relevant bacteria.Microbial biotechnology · 2023Article
- Cell-to-cell non-conjugative plasmid transfer between Bacillus subtilis and lactic acid bacteria.Microbial biotechnology · 2023Article
- Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System.Journal of bacteriology · 2022Article
- Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.Frontiers in immunology · 2022Review
- Intercellular communication and social behaviors in mycobacteria.Frontiers in microbiology · 2022Review
- Cell density, alignment, and orientation correlate with C-signal-dependent gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Article
- Membrane nanotubes are ancient machinery for cell-to-cell communication and transport. Their interference with the immune system.Biologia futura · 2021Review
- Bacterial Vivisection: How Fluorescence-Based Imaging Techniques Shed a Light on the Inner Workings of Bacteria.Microbiology and molecular biology reviews : MMBR · 2020Review
- Bacterial nanotubes as a manifestation of cell death.Nature communications · 2020Article
- Novel method to achieve crystallinity of calcite by Bacillus subtilis in coupled and non-coupled calcium-carbon sources.AMB Express · 2020Article
- The Homologous Components of Flagellar Type III Protein Apparatus Have Acquired a Novel Function to Control Twitching Motility in a Non-Flagellated Biocontrol Bacterium.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously described the existence of membranous nanotubes, bridging adjacent bacteria, facilitating intercellular trafficking of nutrients, cytoplasmic proteins, and even plasmids, yet components enabling their biogenesis remain elusive. Here we reveal the identity of a molecular apparatus providing a platform for nanotube biogenesis. Using Bacillus subtilis (Bs), we demonstrate that conserved components of the flagellar export apparatus (FliO, FliP, FliQ, FliR, FlhB, and FlhA), designated CORE, dually serve for flagellum and nanotube assembly. Mutants lacking CORE genes, but not other flagellar components, are deficient in both nanotube production and the associated intercellular molecular trafficking. In accord, CORE components are located at sites of nanotube emergence. Deleting COREs of distinct species established that CORE-mediated nanotube formation is widespread. Furthermore, exogenous COREs from diverse species could restore nanotube generation and functionality in Bs lacking endogenous CORE. Our results demonstrate that the CORE-derived nanotube is a ubiquitous organelle that facilitates intercellular molecular trade across the bacterial kingdom.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.