ArticleClinical therapeutics2019
Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy.
Article in Clinical therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation.Clinical pharmacokinetics · 2026Observational
- Sedation management and processed EEG-based solutions during venovenous extracorporeal membrane oxygenation: a narrative review of key challenges and potential benefits.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Extraction of ketamine and dexmedetomidine by extracorporeal life support circuits★.The journal of extra-corporeal technology · 2024Article
- Analgosedation in Critically Ill Adults Receiving Extracorporeal Membrane Oxygenation Support.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022Review
- Effects of anesthetic agents on inflammation in Caco-2, HK-2 and HepG2 cells.Experimental and therapeutic medicine · 2021Article
- The multiple faces of ketamine in anaesthesia and analgesia.Drugs in context · 2021Review
- LC-MS based stability-indicating method for studying the degradation of lonidamine under physical and chemical stress conditions.Research in pharmaceutical sciences · 2020Article
- Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy.Journal of pharmaceutical and biomedical analysis · 2020Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeFirst-line management of severe asthma exacerbations include the use of inhaled short-acting β-agonists, anticholinergics, and systemic corticosteroids. Continuous intravenous ketamine given at dissociative doses may be a pharmacologic option in patients who are intubated with life-threatening severe bronchospasm unresponsive to standard therapy. We describe the case of a 44-year-old man admitted to the intensive care unit for status asthmaticus requiring intubation and mechanical ventilation.
methodsThe patient developed severe refractory hypercapnic respiratory failure necessitating additional respiratory support with veno-venous extracorporeal membrane oxygenation (ECMO) therapy. Ketamine treatment was initiated at 0.5 mg/kg/h continuous infusion on the day of admission for pain control and required up-titration to 2 mg/kg/h by intensive care unit day 4 for bronchodilation. Whole blood samples were obtained for pharmacokinetic analysis of ketamine during ECMO.
findingsThe plasma concentration at steady state was 1018.7 ng/mL, with an estimated clearance of 1.96 L/kg/h after up-titration. The V IMPLICATIONS: Compared with healthy adults, there was a 6.5-fold increase in the V
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