Evidence map›Paper›PMID 30929738›Full record

ArticleAmerican journal of human genetics2019

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

Manuel A R Ferreira, Riddhima Mathur, Judith M Vonk, Agnieszka Szwajda, Ben Brumpton, Raquel Granell, Bronwyn K Brew, Vilhelmina Ullemar, Yi Lu, Yunxuan Jiang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  3. Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Manuel A R FerreiraGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia. Electronic address: manuel.ferreira@qimrberghofer.edu.au.
Riddhima MathurGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Judith M VonkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen 9713, the Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen 9713, the Netherlands.
Agnieszka SzwajdaDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden.
Ben BrumptonMedical Reserve Corps Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 1TH, UK; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norges Teknisk-Naturvitenskapelige Universitet, Norwegian University of Science and Technology, Trondheim 7491, Norway; Clinic of Thoracic and Occupational Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim 7030, Norway.
Raquel GranellMedical Reserve Corps Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 1TH, UK.
Bronwyn K BrewDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden.
Vilhelmina UllemarDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden.
Yi LuDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden.
Yunxuan Jiang23andMe, Mountain View, California 94041, USA.
23andMe Research Team23andMe, Mountain View, California 94041, USA.
eQTLGen ConsortiumCollaborators of the eQTLGen Consortium are listed at the end of the manuscript.
BIOS ConsortiumA full list of members appears at the end of the paper.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden.
David A Hinds23andMe, Mountain View, California 94041, USA.
Lavinia PaternosterMedical Reserve Corps Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 1TH, UK.
Gerard H KoppelmanDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen 9713, the Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen 9713, the Netherlands.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm 171 77, Sweden; Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm 171 76, Sweden.

Funding

Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013Medical Research Council MR/J012165/1
6 · The paper itself

Abstract

The extent to which genetic risk factors are shared between childhood-onset (COA) and adult-onset (AOA) asthma has not been estimated. On the basis of data from the UK Biobank study (n = 447,628), we found that the variance in disease liability explained by common variants is higher for COA (onset at ages between 0 and 19 years; h

Indexed as

Genetic Predisposition to DiseaseAdolescentAdultAge of OnsetAllelesAsthmaChildChild, PreschoolFemaleGenome-Wide Association StudyHumansHypersensitivityInfantInfant, NewbornMaleMiddle AgedageallergyasthmageneticgenomeGWASheritabilityonsetoverlaprisk

Identifiers

PMID30929738
PMCPMC6451732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.