Evidence map›Paper›PMID 30929703›Full record

ArticleJournal of psychosomatic research2019

Increased high-frequency NREM EEG power associated with mindfulness-based interventions for chronic insomnia: Preliminary findings from spectral analysis.

Michael R Goldstein, Arlener D Turner, Spencer C Dawson, Zindel V Segal, Shauna L Shapiro, James K Wyatt, Rachel Manber, David Sholtes, Jason C Ong

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of psychosomatic research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00768781 (Augmenting Behavior Therapy for Insomnia With Mindfulness Meditation), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00768781 phase2completednot on this map

Augmenting Behavior Therapy for Insomnia With Mindfulness Meditation

TypeinterventionalSponsorRush University Medical CenterRan2008 to 2013Enrolled54ConditionsInsomniaArmsMindfulness-Based Stress Reduction, Mindfulness-Based Therapy for Insomnia, Wait-List + Behavioral Therapy for Insomnia
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Treatment of chronic primary sleep onset insomnia with Kundalini yoga: a randomized controlled trial with active sleep hygiene comparison.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Michael R GoldsteinDepartment of Psychology, University of Arizona, Tucson, AZ, United States of America.
Arlener D TurnerDepartment of Human Services and Psychology, National Louis University, Chicago, IL, United States of America.
Spencer C DawsonDepartment of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Zindel V SegalDepartment of Psychological Clinical Science, University of Toronto - Scarborough, Toronto, ON, Canada.
Shauna L ShapiroDepartment of Counseling Psychology, Santa Clara University, Santa Clara, CA, United States of America.
James K WyattDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, United States of America.
Rachel ManberDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical School, Palo Alto, CA, United States of America.
David SholtesDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, United States of America.
Jason C OngDepartment of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America. Electronic address: jason.ong@northwestern.edu.
Northwestern University · USRush University Medical Center · USNational Louis University · USSanta Clara University · USStanford University · USUniversity of Arizona · USUniversity of Toronto · CA

Funding

TRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2M
Prevention of Relapse in Recurrent Depression with MBCTR01MH066992 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI SEGAL, ZINDEL · 2004 to 2008
$2.2M
Augmenting Behavior Therapy for Insomnia with Mindfulness MeditationK23AT003678 · NCCIH · STANFORD UNIVERSITY · PI ONG, JASON C · 2007 to 2011
$554k
NCCIH NIH HHS K23 AT003678NHLBI NIH HHS T32 HL007909NIMH NIH HHS R01 MH066992
6 · The paper itself

Abstract

objectiveMindfulness-based interventions (MBI) have been shown to reduce subjective symptoms of insomnia but the effects on objective measures remain unclear. The purpose of this study was to examine sleep EEG microarchitecture patterns from a randomized controlled trial of Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Therapy for Insomnia (MBTI).

methodsSleep EEG spectral analysis was conducted on 36 participants with chronic insomnia (>6 months) randomized to 8-week MBSR, MBTI, or self-monitoring control (SM). Overnight polysomnography with 6-channel EEG was conducted at baseline, post-treatment, and 6-month follow-up. Spectral power averaged from channels C3/C4 across NREM epochs (excluding N1) was examined for within-group changes and relationships with self-report measures.

resultsIncreases in absolute NREM beta (16-25 Hz) power were observed from baseline to post-treatment (p = .02, d = 0.53) and maintained at 6-month follow-up (p = .01, d = 0.57) in the combined MBI groups, and additionally in the gamma (25-40 Hz) range at follow-up for the MBTI group only. No significant changes in these frequency bands were observed for SM. Following mindfulness intervention, NREM beta was positively associated with Five-Facet Mindfulness (FFM) score (rho = 0.37, p = .091) and negatively associated with Insomnia Severity Index (rho = -0.43, p = .047).

conclusionThese results in people with insomnia corroborate prior reports of increased high-frequency sleep EEG power associated with mindfulness training. This change in beta EEG pattern merits further evaluation as a potential marker of the effects of mindfulness meditation on sleep, especially given the paradoxical findings in the context of insomnia. CLINICAL

trial registrationclinicaltrials.gov, NCT00768781.

Indexed as

ElectroencephalographyMindfulnessAdultFemaleHumansMaleMiddle AgedPolysomnographyPsychotherapy, GroupSelf ReportSleep Initiation and Maintenance DisordersArousalEEGInsomniaMeditationMindfulnessSleep

Identifiers

PMID30929703
PMCPMC8497013
OpenAlexW2920540669

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.